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39 Cards in this Set
- Front
- Back
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Dopamine |
cognition, motor function, motivation/decision making, big player in basal ganglia
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Standard (Typical) Anti-psychotics
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Dopamine antagonists
Low potency (less common) - orthostatic hypotension High potency - less anticholinergenic effects but more EPS efects |
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Atypical Anti-psychotics
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Serotonin-Dopamine antagonists
Fewer EPS effects, improves pos and neg symptoms of schizophrenia, improves cognition |
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Side effects of dopamine blockers
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Acute extrapyramical symptoms, Tardive dyskinesia, neuroplectic malignant syndrome.
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NMS
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neuroleptic malignancy syndrome: Fever, Autonomic instability, Leukocytosis, Tremor, Elevated enzymes, Rigidity. Scary, deadly, but reversible if caught
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Acetylcholine
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Cognitive functions, especially memory and learning, stimulates parasympathetic . Agonists may delay cognitive decline
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Norepinephrine
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Mood regulation, attention and arousal, stimulates sympathetic
Deficiency - depression, excess - mania |
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Side effects of norepinephrine blockers
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Depression, hypotension, orthostatic hypotension, sexual dysfunction
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Serotonin
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Mood, sleep regulation, hunger, pain, aggression and libido
Deficiency - depression, excess - mania |
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Histamine
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Alertness, inflammatory response
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Side effects of histamine blockers
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Sedation, weight gain
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Thyroid Stimulating Hormone (TSH), stimulates secretion of T3, T4
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When levels are HIGH - thyroid hypoactive
When levels are LOW - thyroid hyperactive Can be used to treat mood disorders |
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SSRI
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Antidepressant
Selective serotonin re-uptake inhibitors Increase effect of serotonin on receptors |
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SNRI
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Antidepressant
Serotonin-norepinephrine re-uptake inhibitors Agonist for both serotonin and norepinephrine |
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NDRI
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Antidepressant
Norepinephrine-dopamine re-uptake inhibitors Agonist for norepinephrine and dopamine |
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MAOIs
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Antidepressants
Monoamine oxidase inhibitors Block enzymes that breakdown NE and serotonin Increase effect of both NE and serotonin on receptors |
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Tricyclic antidepressants (TCAs)
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Block NE and serotonin receptors
Overdose = death |
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Benzodiazepines
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Antianxiety meds
Enhance GABA Tolerance and withdrawal with these drugs |
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Lithium (Eskalith, Lithobid)
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Mood stabilizer (anticonvulsant), decrease mania
Low therapeutic index, dysrhythmias, seizures |
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Mood Stabilizers
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(Anticonvulsants) decrease mania, enhance GABA
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Chlorpromazine (Thorazine)
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Low potency standard (typical) antipsychotic
- less common, hypotension (only one to know) |
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Haloperidol (Haldol)
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High potency standard (typical) antypsychotic
- higher EPS (1 of 2) |
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Fluphenazine (Prolixin)
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High potency standard (typical) antypsychotic
-higher EPS (1 of 2) |
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Clozapine (Clozaril)
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Atypical antispychotic
-agranulocytosis (1 of 8) |
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Olanzapine (Zyprexa)
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Atypical antispychotic
-weight gain, metabolic syndrome (1 of 8) |
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Risperidone (Risperdal) orthostatic hypotension
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Atypical antispychotic
- orthostatic hypotension (1 of 8) |
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Quetiapine (Seroquel)
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Atypical antispychotic
- orthostatic hypotension (1 of 8) |
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Ziprasidone (Geodon)
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Atypical antispychotic
- orthostatic hypotension, dysrhythmias (1 of 8) |
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Aripiprazole (Abilify)
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Atypical antispychotic
(1 of 8) |
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Iloperidone (Fanapt)
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Atypical antispychotic
- cardiac dysrhythmias (1 of 8) |
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Lurasidone HCL (Latuda
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Atypical antispychotic
- orthostatic hypotension (1 of 8) |
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Divalproex sodium (Depakote)
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Mood stabilizer/anticonvulsant
(1 of 6) |
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Carbamazepine (Tegretol)
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Mood stabilizer/anticonvulsant
(1 of 6) |
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Oxcarbazine (Trileptal)
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Mood stabilizer/anticonvulsant
(1 of 6) |
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Lamotrigine (Lamictal)
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Mood stabilizer/anticonvulsant
*1% reported Stevens-Johnson Syndrome (1 of 6) |
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Gabapentin (Neurontin)
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Mood stabilizer/anticonvulsant
(1 of 6) |
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Topiramate (Topamax)
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Mood stabilizer/anticonvulsant
(1 of 6) |
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Lithium (Lithobid) what, therapeutic level, signs of toxicity |
mood stabilizer 0.5 - 1.3 mEq/L lethargy, muscle weakness, tremors, GI disturbances |
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Phenytoin (Dilantin) what, therapeutic level, signs of toxicity |
anti-seizure 10 - 20 mcg/mL muscular incoordination, nystagmus, dyplopia |
