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35 Cards in this Set
- Front
- Back
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Have disease, look for risk
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case-control
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Have exposure, look for disease
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cohort
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Case-control measure
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odds-ratio
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Cohort measure
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relatie risk
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Assess safety toxicity and pharmokinetics in healthy volunteers
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pahse 1
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Assess eficacy, dosing, and adverse effects in diseased patients
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phase 2
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Compare to standard of care
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phase 3
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detect long term adverse effects
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phase 4
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Attributable risk equals
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a/(a+b) - c/(c+d)
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number needed to treat
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1/absolute risk reduction
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number needed to harm
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1/attributable risk
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looks for differnece in means of two groups
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t-test
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looks for difference between means of 3 or more groups
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anova
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differences between 2 or more percentages
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chi square
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Parental consent not required in
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emergencies, contraceptives, STD tx, pregnancy, drug addiction tx
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Rooting reflex, social smile, responds to voice
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birth-3 months
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crawls, transfer toys, stranger anxiety, peek-a-boo
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7-9 months
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walks, - babinski, speparation anxiety, talks
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12-15 months
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stacks 6 blcoks, 200 words and 2 word phrase
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2 years
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gender identity, toilet training, ride trike, complete snetences
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3 years
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self grooms, hope on one foot, cooperative play, uses prepositions
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4 years
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elderly sleep patterns
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low REM and slow wave sllep
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normal BMI
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18.5-24.9
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obese BMI
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>30
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Awake
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beta waves
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theta waves, light sleep
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stage N1
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sleep spindles, k complexes
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stage N2
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delta waves (high amplitude), slow wave sleep
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stage n3
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sleepwalking, nigth terrors, bedwetting
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stage n3
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beta waves, loss of motor tone, erections
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REM
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TX of bedwetting
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DDAVP or imipramine (depression too)
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Reduced REM sleep drugs
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alcohol, benzos, barbiturates
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principal neurotransmitter of REM sleep
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ACh (NE reduces)
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Depressed sleep patterns
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less low wave, earlier and more REM
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Narcolepsy tx
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modafanil, nighttime sodium oxybate
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