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20 Cards in this Set
- Front
- Back
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Wernicke-Korsakoff Psychosis
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chronic alcoholics
80% LT effects, 17% die |
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Symptoms of WK Psychosis
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1. Bilateral paralysis of abducens nucle
-bilat internal strabismus 2. Paralysis of conjugate gaze -cant move eyes in horiz pln 3. Ataxia incoordination of lower extremities 4. Global confusion state 5. Nystagmus |
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Alcholics malabsorb
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Thiamine
Inhibits transketolase activity esp in hexose-monophosphate shunt inhibits MLF (ipsi 6 contra 3) DO NOT GIVE IV GLUCOSE |
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Neurologic LT effects of Alcohol
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1. atrophy of ant vermis of the cerebellum
2. profound dementia 3. LT and ST memory loss 4. Confabulation (make up stories to fill in gaps) 5. Petachial hemmorages 6. Destruction of mammilary bodies bilaterally 7. Interupted Papez's Loop 8. hemorhages in PAQ Grey matter 9. damage dorsal medial nuc of thalmus |
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Found normal in chronic alcoholics
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EEG
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Kluver-Bucy Syndrome
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1. Herpes simplex destroys medial temporal lobes
esp amygdala and HC 2. profound dementia 3. no new memories inhibit of Papez's Loop 4. Psychic Blindness |
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Diseases that interupt Papez's Loop
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1. Alzheimer's
2. Akinetic Mutism -damage ant cingulate gyri bilaterally 3. Kluver-Bucy Syndrome |
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Psychic Blindness
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seen in Kluver-Bucy Syndrome and Paraneoplastic limbic encephalitis
dont understand what they see, examine everything orally Occipital lobe-->OT Long Assoc Bundles-->Temporal Lobe |
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Lesions in Left Frontal Lobe
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Cause Major depression
no overt symptoms b/c anterior to motor cortex -can be unpresenting tumor |
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Depression
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incapacitating for at least 2 weeks
anhedonia *3 Vegetative Signs 1. dec sleep 2. dec appetite 3. dec libido |
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SPECT and PET
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visualize microvascular blood flow
decreased blood flow in depression and schizophrenia |
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Lesions in Right Frontal Lobe
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result in Mania
symptoms: sleeplessness, very creative, promiscous, impaired judgement |
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Possible cortical irritants
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Blood from hemmorhage
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Paranoid Schizophrenia
Schizophrenia |
1. dec sup temporal gyrus vol
2. auditory hallucinations 3. |
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Planum Temporale
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caudal/post to heschel's gyrus in superior temporal lobe
involved in language and music |
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Schizophrenia
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1. auditory cortex miswired
dec in vol 2. Ventricles much larger 3. dec blood flow to frontal oortex |
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Unique emotional responses
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connections b/w temporal lobe, amygdala, and hippocampus
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Pick's Disease
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1. degenerative disorder of CNS
2. affects Frontal and/or Temporal lobes 3. NEVER effects Parietal/Occipital 4. Frontal Lobes affected first |
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Pick's Disease Symptoms
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1. early 50s, more prev in women
2. behavioral problems precede dementia 3. Autosomal dominant (maybe) 4. Frontal Disinhibition (*) 5. cannot control what they do or say 6. incontinent |
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Pick's Vs. Alzheimer's
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Alz-->effects ALL Lobes of brain
Picks-->only effects Frontal and Temporal Alz--> disease of association cortex Picks-->Lobar degen disorder |
