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9 Cards in this Set
- Front
- Back
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What is protein adsorption?
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adhesion of molecules to the surface
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What is the adsorbate on the surface composed of?
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ions, water, and proteins
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Why is controlling protein adsorption important for biocompatibility?
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the body reacts to the surface with the adsorbates
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What surface properties have the largest effect of adsorption?
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1) Surface hydrophobicity
2) Surface charge |
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What is a way that surface charge occurs?
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via dissociation of ionizable surface groups
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How does surface charge affect adsorption?
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A significant surface charge can work to either attract a protein or repel it, it depends on the charge of the protein
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How do steric concerns affect adsorption?
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If flexible hydrophylic chains (PEG) are placed on surface, they may move too fast for proteins to bind to them
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How does surface roughness affect adsorption?
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High roughness may provide places to trap proteins in valleys
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What are some things that can be done to alter adsorption?
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Surface modification such that bulk properties are unaffected
1) Thin layer - to minimize effect on bulk 2) Resistance to delamination- separation of layers 3) Simple and robust- to promote commercialization 4) Means to discourage surface rearrangement- surface tension |
