• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/8

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

8 Cards in this Set

  • Front
  • Back
What is the chemical breakdown of a material mediated by a component of physiological environment
biodegredation
how do synthetic polymers degrade?
Hydrolysis or or in response to enzymes
How do natural polymers degrade?
enzyme-induced cleavage
Why is hydrolitic cleavage more consistent that enzyme cleavage?
LOOK UP IN NOTES!!!
What are two mechanisms through which polymers undergo hydrolysis?
bulk and surface degradation
What is bulk degradation?
Rate at which water ingress is greater than the rate at which polymer is converted to its degradation products
1) Dimensions remain the same
2) Materials undergo rapid decrease in mechanical properties leading to collapse
What is surface degradation
rate of water ingress is less than the rate at which polymer is converted into its degradation products
Must have hydrophobic regions to keep water out
1) implant will decrease in thickness but maintain much of its mechanical integrity
2) Continual turnover of surface make it difficult to integrate with surrounding tissue
What type of hydrolysis is better for sustained drug delivery?
surface degradtaion