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38 Cards in this Set
- Front
- Back
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What are first line therapies for depression? |
SSRIs SNRIs bupropion mirtazapine All considered equally efficacious |
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What is a commonly used rating scale for depression? |
HAM-D Hamilton Rating Scale for Depression |
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T/F: A response to depression therapy is usually defined as a 25 % reduction in the HAM-D score. |
False. 50% reduction. |
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Fluvoxamine is an effective antidepressant but is technically only indicated for what disease state? |
OCD |
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Which SSRI has the longest half life? The shortest? |
longest - Fluoxetine 1-4 days shortest - Fluvoxamine - 15 hours |
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Venlafaxine has primarily a serotonin effect at doses lower than what? |
150 mg/day |
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What SSRIs are CYP2D6 inhibitors? |
Fluoxetine, paroxetine |
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What pregnancy class is Paroxetine? |
D |
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Which antidepressant medications should be avoided in patients w/ seizure disorder? |
Bupropion Vilazodone TCA's |
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T/F: Mirtazapine can cause orthostatic hypotension |
True |
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What anticonvulsants can be used as mood stabilizers for bipolar disorder? |
Divalproex
Carbamazepine Topiramate Lamotrigine |
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What life threatening condition can occur when taking divalproex? |
Pancreatitis |
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T/F: The same serum concentration range (4-12 mcg/mL) for carbamazepine should be used for pt's with seizures and bipolar disorder. |
True |
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ALL atypical antipsychotics have received FDA approval for use in acute mania or mixed episodes EXCEPT for which two? |
Clozapine Iloperidone |
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T/F: Risperdal Consta and Abilify Maintena must be used in combination therapy for bipolar maintenance. |
False. Either can be used as for maintenance as MONOTHERAPY. |
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What is the drug of choice for depression in pt's w/ bipolar type II? |
Quetiapine *Lamotrigine is a reasonable alternative* |
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Fluoxetine in combination w/ what drug is approved to treat depression in patient's w/ bipolar disorder type I? |
Olanzapine |
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What class of drugs is first line for bipolar depression disorder? |
Mood stabilizers |
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Name the four phases of schizophrenia |
1. Prodromal 2. Acute 3. Stabilization 4. Stable |
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What is the drug of choice to treat pt's on SGAs that are experiencing akathisia? |
Lipophilic Beta blocker (e.g Propranolol) |
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Which two SGAs carry the highest likelihood of weight gain? |
clozapine olanzapine |
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Which SGAs carry risk for QTc prolongation? |
Paliperidone Ziprasidone Clozapine Asenapine Iloperadine |
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T/F: Acamprosate is metabolized by the liver |
False. |
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Thiamine is given to alcohol abuse patients to prevent what syndrome? |
Wernicke-Korsakoff |
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Buspirone is only recommended for treatment of what type of anxiety disorder? |
GAD, generalized anxiety disorder |
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What medications are specifically noted as "not effective" for treatment of panic disorder? |
Buspirone Beta blockers antihistamines antipsychotics bupropion trazodone |
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What medications are considered first line treatment for panic disorder? |
1. SSRIs (escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) 2. venlafaxine 3. duloxetine |
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What drugs are first line treatment for PTSD? |
SSRIs- fluoxetine, sertraline, paroxetine |
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Should benzodiazepines be used in pt's w/ PTSD? |
No, not effective |
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Ramelteon and zolpidem vshould be avoided in patients that suffer from what specific type of sleep disorder? |
Sleep apnea |
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What is the appropriate starting dosage for the medication eszopiclone? |
1 mg as of May 2014 |
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What is the typical onset time a pt may develop delirium tremens? |
3-5 days after acute w/drawl |
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What three medications can be considered for chronic alcohol abuse therapy? |
1. Disulfiram (assoc. w/ hepatotoxicity) 2. Naltrexone (assoc. w/ hepatotoxicity) 3. Acamprosate (renal) |
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Buprenorphine is metabolized by what CYP enzyme? |
3A4 |
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What length of time should varenicline be continued for? |
A total of 12 weeks. Then another 12 weeks if needed. |
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T/F: Varenicline can be combined w/ bupropion for smoking cessation |
True |
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How many days before the smoking "quit date" should bupropion SR be initiated? |
7 days |
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T/F: Smoking cessation patients may use a nicotine patch in combination w/ bupropion SR. |
True |
