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19 Cards in this Set
- Front
- Back
|
Oxaloacetate
|
Condensation-citrate synthase
|
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Citrate
|
Dehydration
*aconitase |
|
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Aconitate
|
Hydration
*aconitase |
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Isocitrate
|
Decarboxilation
a-ketoglutarate dehydrogenase complex |
|
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a-ketoglutarate
|
succinyl coA synthetase
|
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Succinyl-CoA
|
substrate level phosphorylation-Succinyl-CoA synthetase
|
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Succinate
|
Dehydrogenation
Succinate Dehydrogenase |
|
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Fumarate
|
Hydration-fumarase
|
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Malate
|
Dehydration-
malate dehyrogenase |
|
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ATP
|
ATP - (AMP +). pyruvate DH
ATP - (ADP +)citrate synthase ATP - (ADP +) isocitrate DH |
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NADH
|
NADH - (NAD+)-pyruvate DH
NADH - citrate synthase NADH - a-ketoglutararate DH Complex |
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Succinyl CoA
|
Succinyl CoA
inhibit citrate synthase & A-ketoglutarate DH complex |
|
|
Acetyl CoA
|
-PFK-1
+Pyruvate CArboylase -pyruvate kinase -pyruvate DH |
|
|
Succinyl CoA
|
-citrate synthase
-a-ketoglutarate complex |
|
|
B-oxidation
|
1. Dehydrogenation (FAD)
2. Hydration (H2O) 3. Dehydrogenation (NAD) 4. CoASh enters *Fatty-acyl CoA---Acetyl CoA --Trans enoyl CoA --b-hydroxylacetylCoA --b-ketoacyl coa |
|
|
Hormonal Regulation
Insulin & Glucose Regulation |
Carb. = +blood glucose=+insulin=+phosphatase activity=+malonyl-CoA=-carnitin-acyl transferase=-b-oxidation
NO carb.=glucagon=+PKA=-ACC=-malonyl coa=carnitineacyl-transferase=fatty acyl in mitochondria=B-oxidation |
|
|
Vitamin B12
|
connverts (along with methylmalonyl-CoA mutase)
methylmalonyl-CoA to succinyl CoA |
|
|
Urea Cycle
|
Carbomoyl phosphate-citrulline-(aspartate)arginino/succinate-(fumarate)arginine-(urea)ornithine
arginine + N-acetylglutarate+CPSI +carbomoyl phosphate |
|
|
Ketone Formation
|
Acetyl CoA + Acetyl Coa (CoASH);
Acetoacetyl CoA (H2O Acetyl CoA); B-hydroxyB-methyl glutaryl-CoA (acetyl coA leaves) acetoacetate; acetone, b-hydroxybutyrate |
