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224 Cards in this Set

  • Front
  • Back
Define genetic Susceptibility
Having the genes that, given the RIGHT ENVIRONMENT, would allow a given trait or disease.
What is a "caveman environment"
alteration in genes --> decreased energy use and increased storage (don't use unnecessary E) --> increased survival --> increased reproduction --> altered genes are common in pop. --> increased survival of pop.
What are "thrifty genes"
genes selected through evolution.
- Increased storage of energy and decreased basal energy use.
thrifty genes were advantageous for what kind of environment.
a caveman environment when going days without food was a possibility.
What is an obesogenic environment?
our environment is allowing us to store E and not use the E that we have inefficiently. -->we still store all our E efficiently causing adipose storage.
"it refers to an environment that promotes gaining weight and one that is not conducive to losing weight."
what are single gene conditions?
a specific condition that leas a person to develop diabetes/obesity DESPITE their environment ex. live in environment scarce of food and still develop obesity.
- rare
Define heritability
the state of being capable of being passed on from one generation to another.
heritability is due to...
genes
environment (including "taught" behaviors")
Combo
Number of obese parents connected to lifetime risk for children
1 parent - 20-50%
2 parents - 50-75%
Number of affected parents with T2DM and the lifetime risk for children
1 - 40%
2 - 70%
Effects of an undernourished mother (PN environment)
Decreased prenatal nourishment --> prime genes for efficient use and storage of energy) --> baby with low birth weight and PRIMED genes to be very efficient with it use of energy it gets --> increased of kcal and decrease of physical activity --> adult obesity
Effects of an over-nourished mother (PN environment)
increased prenatal nourishment --> prime genes for improper use and storage of energy --> baby with HIGH birth weight and primed genes --> increased kcal food and decreased physical activity --> adult obesity.
Mother with DM and its PN effects
Increased prenatal nourishment and/or prenatal insulin resistance --> prime genes for improper use of storage of energy --> baby with high birth weight and or PRIMED genes --> increase kcal food and decreased physical activity --> DM in adulthood
High birth weight
>9 lbs
Obesogens do what
disrupts our endocrine system making a person develop more fat cells.
what is "toxic overload"
something in our environment that is leading people to become overweight.
define obesogen
a synthetic chemical that is thought to "cause" obesity.
What is the obesogen hypothesis
obesogens bind to hormone receptors...
immature adipocytes -->
exposed to obesogens -->
increased adipocytes -->
increased ability to store TG -->
also with an increase in kcal food and decrease in physical activity
what product is seen as an obesogen?
Bisphenol A (BPA products)
what is BPA?
used to make plastics and coatings
- in a 2012 study, there were higher levels of BPA in obese children.
what type of cells is BPA found in?
adipose (Fat cells)
it is a estrogen hormone-like substance
some may say evolution is working against people to lose weight. How so?
- caveman genes which encourages efficient storage of all energy.
- this was helpful for an environment where food is scarce.
what role does race/ethnicity play in the "causes of DM and obesity?"
-shared genes
-shared environment - an environment that does/does not encourage physical activity
Explain how the prenatal environment can impact risk for DM and obesity in adulthood
answer later
Is BPA definitely an obesogen?
No, it's a highly controversial theory.
T/F Having a genetic susceptibility for T2DM means that a person is definitely be affected.
False, your chances just increase.
My mom is obese. How does this impact my risk for T2DM?
My risk is higher because of genes and environment, etc.
T/F Thrifty genes code for obesogens
False
High fat in your diet can be problematic because...
increased kcal
easily processed to be stored
refined (processed) foods in your diet can be problematic because
easily processed/stored
over-sweetened food in your diet can be problematic because...
increase in empty kcals
how much more kcal (%) do we eat compared to ten years ago?
31% more
why do we eat so much? (12 things)
1. biologically programmed to eat a lot
2. food tastes much better (infused with salt, fat, and sugar).
3. Increased availability/access
4. increased variety (types, quantity, and quality)
5. Decreased relative cost.
6. portion distortion (serving does not equal appropriate portion.
7. eat out more (higher kcal/meal)
8. Marketing: supersize me! ($ value vs. nutrition).
9. Maladaptive meal patterns.
10. Social/cultural meaning of food/eating.
11. Unmet psychological needs (eating your feelings)
12. Takes herculean effort not to overeat.
How we should move (two ways to have an active lifestyle)
1. aerobic exercise
2. muscle strengthening
How to have a moderate/vigorous aerobic lifestyle
moderate - 150 minutes/week.
vigorous - 75 minutes/week
How to properly strengthen muscles for an active lifestyle
2x week - lifting, carrying, etc.
% of people that do physical activity during leisure time.
40%
% adults that meet minimum physical activity requirement.
3%
2010 - % of people that have a job with physical labor
<20%
50s - % of people that have a job with physical labor
50%
six reasons why we don't move
1. we don't have to
2. less time for "play"
3. concerns about safety
4. concerns about other's viewing them.
5. Fuss factor
6. It's work - our bodies want to relax
discuss factors that lead us to consume "too much" often without knowing it
portion size has increased
cheaper to buy foods in bulk
it's difficult to refrain from overeating
etc.
discuss how changes in physical activity norms are related to obesity and T2DM
physical activity is not encouraged as much as relaxing is which can directly effect a person's motivation to lose weight/how they feel when they try to lose weight.
T/F americans consume about the same amount of kcal/day now, as they did about 30 years ago.
False
T/F per meal, American generally consume more kcal when they eat out that if they were to eat food prepared at home
True.
James walk 15 minutes to and from class at a moderate pace on M, W, and F. Is this enough physical activity to meet the US PA Guidelines
It should be at least 150 minutes/week of moderate exercise of 75 minutes of vigorous exercise.
define mortality
death, my friend
% of deaths due to poor diet and inactivity
16.6%
define morbidity
health problems
define diabetes
medical condition resulting from the lack of insulin or the inability of insulin to work properly.
types of eye problems that occur with diabetes
blurred vision
retinopathy
define lens
transparent body that focuses light on retina.
retina
back part of the eye that sense light and tells brain what you are seeing.
how does diabetes cause eye problems
glucose binds to proteins in the eye cells
the eye cells weaken/do not function properly.
how does diabetes cause blurred vision
fluid changes in lens
how does one resolve blurred vision
resolves with sustained glucose control
define diabetic retinopathy
damage to cells/tissue of the retina
- capillaries
- neurons
% of people with T2DM also have retinopathy
>50%
definitive characteristic of retinopathy
"cotton wool spots" dotting the lens.
types of retinopathy
Nonproliferative
Proliferative
if not under control, what doe retinopathy lead to?
retinal detachment
blindness
prevention/treatment for eye problems
good glucose control
laser surgery
other types of eye surgery
function of the kidneys
organs that detoxify our blood
nephrons filter your blood and puts it into the urine to be flushed out.
what is the kidney problem that can occur if you have diabetes
diabetic nephropathy
define diabetic nephropathy
damage to kidney capillaries due to exposure to high glucose levels.
what does diabetic nephropathy result in (three things)
- wastes/toxins stay in blood
- proteins/nutrients excreted in urine
- long term --> kidney failure (ESRD)
% DM have symptoms of kidney damage
30%
% with ESRD because of DM
~40%
symptoms of diabetic nephropathy (4)
fluid build up
sleep problems
vomiting
weakness
dialysis is...
a machine that cleans up the blood for you.
how do you cure diabetic nephropathy
kidney transplant.
T/F as one's BMI increases one's risk for death decreases
False
T/F the longer the person with DM's blood sugar is "out of control", the higher her risk for developing diabetic retinopathy
True
T/F a nephron is a damage neurons
False, it filter blood out of our kidneys.
Define diabetic neuropathy
Damage to nerves in the body due to high glucose
% of people with DM have some degree of neuropathy
60-70%
explain how one obtains diabetic neuropathy
glucose increases (binds to neurons; upsets neuronal chemical balance; damage blood vessel cells feeding neurons) --> decreased function/ neuron death --> neuropathy
types of diabetic neuropathy
peripheral
autonomic
focal
explain autonomic diabetic neuropathy
problems with neurons taking signals from heart, gut, lungs, bladder, bowel, etc --> problems controlling such organs.
explain focal diabetic neuropathy
just one part of your body that is affected by the neuropathy
symptoms of diabetic neuropathy
pain
numbness/tingling of hands and feet
problems controlling a certain body part
describe relationship between obesity and mortality
if obesity is not kept under maintenance, it can cause severe issues ranging from kidney disfunction to organ failure, which can lead to death.
Deepika is a 24 year old woman who is obese. She has no other chronic health condiitons. Should she be concerned about her weight? Why or why not?
Yes.
No current issues does not mean no future issues.
describe how glucose levels are linked to eye and kidney for persons with DM.
eyes: glucose binds to proteins in the eye cells --> eye cells weaken/do not function properly (blurred vision; retinopathy; etc.)
kidneys: damage to kidney capillaries due to exposure to high glucose levels (toxins stay in blood; proteins excreted into urine; etc.)
what is a peripheral neuropathy?
meaning nerve damage in the peripheral nervous system. Only nerves outside of the brain and spinal cord are involved, so peripheral neuropathy does not include nerve damage in the central nervous system.
% people with DM have DM-related skin problem
30%
explain the connection between DM and infections
blood glucose (decreased immune response; optimal environment bacteria growth; decreased blood flow) --> increased risk of infection.
if an infection spreads beyond care, what is the last option a doctor has to stop the spread?
amputation.
why does amputation occur?
uncontrolled, spreading infection.
% of non-traumatic lower-limb amputations occur in people with DM.
>60%
% of men over 50 with DM that experience Erectile dysfunction
50-60%
cause of Erectile Dysfunction in men
blood vessel and nerve damage
psychological factors
% of women who have trouble with glucose levels during their period
70%
How does DM create pregnancy problems
pregnancy alters the ability to process glucose.
- changes diabetic management
Higher maternal blood sugar
- increased fetal risk; maternal risk
% risk of birth defects due to DM
3-5%
what trimester can be effected the most with high blood sugar
first trimester
types of birth defects caused by DM
neural tube defects (spina bifida)
heart defects
large sized babies
fetal death
T/F children of women with DM do not have a larger probability of developing DM themselves.
False, they are at an increased risk compared to a child with a mother w/o DM.
What are the pregnancy risks from DM
Pre-eclampsia (High BP, protein in urine)
c-section vs. vaginal birth
c section has more possible complications
- longer recovery time, big womb that is at risk of infection.
How does increased blood glucose increase risk for infection/skin problems?
high blood glucose decreases immune responses, and creates an optimal environment for bacteria to grow which increases risk of infection.
How common is ED in men with DM?
Very common. Men over the age of 50 have a 50-60% chance of having erectile dysfunction.
What types of reproductive consequences does DM have for women?
your period is messed up...answer later.
Nephrons are damaged in DM by thrifty genes
False
Yeon has T2DM. Should she get a flue shot? why or why not?
yes, she is more susceptible to varied illnesses.
T/F Women may have prenatal testing to see if their baby has DM.
False, cannot test for Prenatal diabetes
% of women who have Polycystic Ovary Syndrome (PCOS)
5-10% of women
what causes PCOS?
increased production of androgens in the body
also
increased adiposity --> increased size of fat cells --> fat cells can secrete hormones at a higher level --> increases influence of development of PCOS>
What is coronary heart disease
narrowing of the blood vessels that bring blood to the heart muscle itself.
what causes a narrowing of the heart vessels
atherosclerosis
What is peripheral artery disease
diseased vessels that bring blood to non-heart parts of the body.
what causes Peripheral artery disease
atherosclerosis and HTN
what can peripheral artery disease lead damage to...
kidneys
legs
arms
feet
% T2DM related deaths due to CVD
50-80%
T/F CVD occurs after DM
False. CVD begins before DM is diagnosed
what is blood pressure?
BP - measure of the force pushing outwards on the arterialwalls
healthy BP
<120/<80
unhealthy (HTN) BP
>=140/>=90
HTN link to athersclerosis
higher BP --> blood vessel damage --> great environment for atherosclerosis --> plaque formation
HTN link to kidney disease
increased BP --> Rena caps get damaged --> decreased kidney functioning --> renal disease
How is HTN the silent killer?
generally no clinical signs
only diagnostic by BP check
WHat is a myocardial infarction?
Heart attack
define MI
death of/damage to the heart muscle b/c heart muscle's blood supply is severely lowered or stopped.
cause of MI?
Thrombosis in coronary arteries
- blood clot blob that clogs the artery
- athersclerosis
How common is PCOS and what are the symptoms
relatively commom - about 5-10% of women have it.
symptoms include abnormal menstrual cycle; increased acne, excess body hair, "dirty skin"
Tara was just diagnosed with PCOS. As treatment, her doctor prescribed her both BC pills and DM medication. Why?
BC to help regulate her menstrual cycle
DM to assist with her possible insulin resistance.
T/F obesity, but not DM, increases one's risk for CVD
True
Anita has no known medical problems and feels "great". However, she recently had her blood pressure checked. It was 153/87. SHould she be concerned?
Yes, anything higher than 140/90 is HTN.
T/F coronary arteries bring blood the brain
false, the heart
T/F MI are caused by thrombosis
true
Define strok
death of/damage to the brain beause the brain's blood supply has severely decreased or stopped.
what is stroke due to?
atherosclerotic embolus
types of stroke
ischemic/TIA
hermorrhagic
what is ischemic/TIA stroke
mini-stroke - blockage but blood vessels don't actually explode
what is a hermorrhagic stroke
the blood vessel actually bursts
Acronym for stroke symptoms
FAST
Deconstruct FAST
it's for the signs of stroke...
F - face drooping
A - arm weakness
S - speech difficulty
T - time to call 911
What's a syndrome
constellation of clinically important features that are often found together
-physical
- biochemical
what is metabolic syndrome (MetS)
constellation of clinical features that increase risk for CVD, MI, and stroke
prevalence of MetS in the US
20-40% adults in US (20+ years)
in your sixties, who is more at risk for MetS, women or men?
women
what are lipoproteins
complex proteins that transport fats to body cells
what is the components of lipoproteins
TG
Protein
Cholesterol
is cholesterol needed by the body?
yes
20% in from our diet
80% is made from our liver
is more cholesterol in your body because you ate it or made it?
made it
what are cholesterol-lowering drugs meant to target?
suppress cholesterol production in the liver.
Is HDL good or bad?
good - HDL brings loose lipids and cholesterol back tot he liver
is LDL good or bad
bad - drops cholesterol and lipids into cells
a diagnosis of MetS means that the patient had to have # of the specific clinical features
3 or more
synergistic
the three risks (of MetS) work in tandem will increae the risk rather than just one risk plust another risk plust another
what is the MetS diagnostic riteria
increase abdominal obesity
increased TG
decreased HDL
Increased BP
increased blood sugar
for men and women, what signifies as abdominal obesity?
men - waist circum of > 40 in.
Women - waist circum. of > 35 in.
amount of TG in body that is dangerous for M and W
M and W - >/= 150 mg/dl
amount of HDL in body that is dangerous for M W
decreased to
M - <40 mg/ dl
W - <50 mg/dl
BP that is dangerous for M and W
M and women >/= 130/85 mmHG
blood sugar level that is dangerous for M and W
M and women >/= 100 mg/dl
How does waist circumference increase CVD risk
increase lipids in blood --> increased abdominal uptake of "loose" fat --> increase form of atherosclerotic plaque.
How does increased TG increase CVD risk
increased abdominal risk "loose fat" --> increases atherosclerotic fat
how does decreased HDL increase CVD risk?
Decreased HDL --> less HDL to pick p loose lipids --> increased chance for "loose" lipids to cause damage --> increased form of atherosclerotic plaque.
High blood pressure causes increased CVD risk...
increased chance for blood vessel damage --> increased chance of immune response --> increased formation of atherosclerotic plaque
how does high blood sugar increase CVD risk?
increased blood sugar --> good conditions for fomatin of atherosclerotic plaque
if LDL is bad why does the body make it?
because our cells need cholesterol. Just too much cholesterol in the body can cause too much of it in the cells.
- Bonus: Warren has high LDL’s. He eats a low cholesterol diet for 6 months and then has his LDL levels checked again. The result shows that his LDL level is virtually the same. How can this be? (Hint: where does MOST cholesterol come from?)
he needs medication to suppress the cholesterol production in his liver. That is the real problem
T/F MetS increases one's lifetime risk for stroke and MI
true
T/F most cholesterol in the boy comes from our diet
false, liver
T/F high LDL level is one of the 5 clinical features of MetS
false.
which lipoprotein is thought to protect against CVD? Why?
HDL, picks up loose lipids left by VLDL
how does cancer "come about"
carcinogenesis
cause of all cancers
mutations in genes for cell division control.
define carcinogen
substance that initiates cancer by causing mutation in gene.
- changes o the gene
what's a cancer promoter
a substance that promotes caner cell development.
- promotes the cancer cell development (doesn't necessarily change the genome).
Phase 1 of cancer development
initiation.
- organ/tissue with normal growing cells ---> exposed to carcinogen --> mutation in growth control genes --> organ/tissue with abnormally growing cells.
Phase 2 of cancer development
Promotion
Abnormally growing cells --> promoter comes in --> increases division/growth of abnormal cells and daughter cells --> lots of abnormal cells to organ/tissue.
Phase 3 of cancer development
progression
lots of abnormal cells in organ/tissue --> promoter --> some abnormal cells migrate (METASTASIZE) --> cancer cells in multiple tissues/organs.
what is benign cancer
growth only in one place.
danger if presses on vital organ
once removed, usually won't come back
malignant cancer
ability to metastasize/invade and destroy surround tissues.
fast, uncontrolled growth
comes back
cancer death due to OW/obesity?
M - 14%
W - 20%
fraction of ALL cancer in the US that could be prevented if adults were at a healthy weight.
1/3
DM med that is linked to decreased cancer risk
metformin
CA linked to DM in what types
pancreas
bladder
liver
CA linked to obesity/ow in what types
breast (post-meno)
colorectal
endometrial
what three effects does obesity and DM influence which can lead to cancer?
increased # and size of adipocytes.
Increased #, types, and activity of immune cells.
increased insulin resistance
how is increased # and size of adipocytes linked to cancer
abnormal hormone levels (estrogen and leptin)

Hormones promote abnromal growth
how is increased #, types, and activity of immune cells linked to cancer
abnormal release lipids and immune cell-derived oxidants.

Oxidants initiate DNA damage.
Abnormal lipids binding to enzymes promote abnormal growth.
How is increased insulin resistance linked to cancer
increase glucose ad increase insulin and other metabolic changes

creates and environment that promotes abnormal growth.
which cancers are more common in people with DM?
pancreas
bladder
liver
which cancers are more common in people with obesity?
breast (post-meno)
endometrial
colorectal
what i the difference between benign and malignant CA?
benign is concentrated in one area - once removed, it should not come back.

malignant spreads through the body and can come back.
T/F carcinogenesis is the production of synthetic chemical to treat CA
False, they cause cancer.
T/F people with obesity are at an increased risk for colorectal CA
true
how does excess adipose lead to cancer
increased hormone secretion
increased number and types of immune cells
increased insulin resistance
morbidity
health problems
mortality
death
what is osteoarthritis
joint disease that affects the cartilage mostly
what is cartilage
hard, slippery coating on the end of each bone.

allows bones to glide
absorbs and shock of movement.
explain the process that causes osteoarthritis
thinning of cartilage --> bones rub --> joint damage --> pain; swelling; loss of mobility
affects joints with obesity
knee
lower back
hands
hips
Sleep apnea definition
1+ pauses in breathing or shallow breaths during sleep
symptoms of sleep apnea
snoring
pauses in snoring --> gasping
sleepiness during the day
obesity and sleep apnea
increased fat stored around neck

- decreased airway size
- increased risk for airway blockage.
obesity hypoventilation syndrome chain of events
severe obesity -->
apnea -->
blood oxygen low, carbon dioxide high -->
increased strain on heart
What does CPAP stand for?
continuous positive airway pressure

Tx for apnea
define gallstones
solid deposits that form int he gallbladder
medical term for gallstones
cholelithiasis
how do gall stones form?
form when bile components join together and make crystals
% of adults affected by gallstones
10-15%
what tissue is damaged in OA?
cartilage
T/F Dementia is linked to obesity but not DM
false, both
T/F all obese persons have psychological problems
false, our society is built to make us heavy
people with DM are (# of times) more likely to suffer from depression that unaffected persons
two times more
does obesity/DM affect men and women the same way, from a psychological point of view? Why or why not?
body image is more negative in women than men.
define stigma
label that associates a person to a set of characteristics that form a stereotypes
weight bias definition
stigmatization of overweight and obese persons because of their weight status
in a OW/obese study on weight bias...
% weight bias from a physician
% weight bias from nurses
% weight bias from dietitians
69% physician
46% nurses
31% dietitians
stunkard's classic silhouettes were what
pictures of different physiques to identify a person's self body perception
results of the Stunkard silhouette study
adults can't accureately tell someone's health status by physique alone.
NHANES created an assessment on
perception of weight status
weight-loss attitudes
diet
physical activity
what were the results?
most subjects accurately perceive weight status
- 23% reported misperception.
why are misperceptions of weight bad?
misperception
less motivation to improve own health behaviors
less awareness of overweight/obese children's risks/needs
less overall public health/psych
which groups assessed int he Rudd Report were most frequently reported as showing weight bias?
health professionals
how can health professionals reduce weight bias
being more sympathetic towards patients of a heavier weight
- do not immediately make assumptions due to a person's weight.
[ physically accommodating waiting room.
T/F the media promotes weight bias
true
how does culture/ethnicity influence weight perception
varied perceptions of what "healthy weight" looks like
- in some cultures obesity does not necessarily equal bad.
Definition of vanity sizing
change to standardized measurements for clothes, as a means to increase sales.
estimated amount of money that is directed towards obesity-related conditions in healthcare
~ $147-210 billion/year