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32 Cards in this Set
- Front
- Back
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what type of drug bind albumin best
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hydrophibic drugs (not water soluble)
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why must you becareful about dosing drugs to prematures infants
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their renal system is not fully developed, so excretion of drugs via the renal sys is decreased
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what are the drugs that induce CYP450
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ETOH, barbituarate, phenytoin, rifampin, methadone, levadopa, OCP (one pharmaceutical brings about rapid liver metabolism)
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what are the drugs that inhibit CYP450
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sulfonamids, phenylbutazone, coumadin, dicumarol, chloramphenicol, isoniazid, cimetidine, dicumarol (some pharmaceutical classes inhibit drug catabolism)
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what drugs compete for the transporters in the renal system
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sulfonamides, probenecid, pens, salicylates, thiazides + Not a drug….. uric acid (some pharmaceuticals plus urate stop transporters)
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AG + Loops =
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increase nephrotoxicity and ototoxicity
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MAO + SSRI =
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may cause serotonin syndrome
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MAO + TCA =
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may cause Serotonin syndrome or severe SNS activation
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antiarrhythmic + FQ =
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may prolonged QT
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cation drugs or citric acid + FQ =
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poor FQ absorption
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alcohol or rifampin + isoniazid =
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may cause liver damage
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bone marrow toxicity
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most chemo agents, chloamphenicol, gancyclovir, zidovudine, interferon, flucytosine, carbamazepine
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HEPATOTOXICITY (very ill hepatitis pts never ingest azoles)
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imidazole, interferon, nevirapine, HMG CoA inhibitors, valproic acid, isoniazid
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NEPHROTOXICITY (nephro- a FANAtiCC about sex)
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AG, foscarnet, cidofovir, NSAIDS, cyclosporine, amphotericin
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TENDON RUPTURE
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quinolones
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DVTS
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ralozifene, tamozifen, estrogens/progesterones
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ORTHOSTATIC HYPERTENSION
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alpha blockers, TCAs
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HYPERTENSIVE CRSIS
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MAO - I, TCAs
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Serotonin syndrome
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MAO I, TCA, SSRI, SNRI, pseudoephrine decongestants
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flushing
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naicin
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seizure
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meperidine
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G6PD EXACERBATION
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really any drug, but sulfas and primaquine
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DRUG INDUCED LUPUS
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hydralazine, procainamide
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MALIGNANT HYPERTHERMIA
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HALOthane
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naion
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PDE-5 inhibitors
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ototoxic
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PDE-5 inhibitors, and Ags
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neural tube defects
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mom's on carbamazepine, valproic acid
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ebstein's anomaly caused by
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mom's on lithium
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serum proteins can spew
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easily removed from albumin (sulfonamides, phenybutazone, coumadin, sulfonylureas)
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one pharmaceutical brings about rapid liver metabolism
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OCP, phenytoin, barbituates, alcohol, rifampin, levadopa, methadone
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some pharmaceutical classes inhibit drug catabolism
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sulfonamides, phenylbutazone, chloramphenicol, isoniazid, dicumarcol, cimetidine
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some pharmaceuticals plus urate stop transporters
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sulfonamides probencid pencillin uric acid salicylates thiazides
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