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32 Cards in this Set

  • Front
  • Back
what type of drug bind albumin best
hydrophibic drugs (not water soluble)
why must you becareful about dosing drugs to prematures infants
their renal system is not fully developed, so excretion of drugs via the renal sys is decreased
what are the drugs that induce CYP450
ETOH, barbituarate, phenytoin, rifampin, methadone, levadopa, OCP (one pharmaceutical brings about rapid liver metabolism)
what are the drugs that inhibit CYP450
sulfonamids, phenylbutazone, coumadin, dicumarol, chloramphenicol, isoniazid, cimetidine, dicumarol (some pharmaceutical classes inhibit drug catabolism)
what drugs compete for the transporters in the renal system
sulfonamides, probenecid, pens, salicylates, thiazides + Not a drug….. uric acid (some pharmaceuticals plus urate stop transporters)
AG + Loops =
increase nephrotoxicity and ototoxicity
MAO + SSRI =
may cause serotonin syndrome
MAO + TCA =
may cause Serotonin syndrome or severe SNS activation
antiarrhythmic + FQ =
may prolonged QT
cation drugs or citric acid + FQ =
poor FQ absorption
alcohol or rifampin + isoniazid =
may cause liver damage
bone marrow toxicity
most chemo agents, chloamphenicol, gancyclovir, zidovudine, interferon, flucytosine, carbamazepine
HEPATOTOXICITY (very ill hepatitis pts never ingest azoles)
imidazole, interferon, nevirapine, HMG CoA inhibitors, valproic acid, isoniazid
NEPHROTOXICITY (nephro- a FANAtiCC about sex)
AG, foscarnet, cidofovir, NSAIDS, cyclosporine, amphotericin
TENDON RUPTURE
quinolones
DVTS
ralozifene, tamozifen, estrogens/progesterones
ORTHOSTATIC HYPERTENSION
alpha blockers, TCAs
HYPERTENSIVE CRSIS
MAO - I, TCAs
Serotonin syndrome
MAO I, TCA, SSRI, SNRI, pseudoephrine decongestants
flushing
naicin
seizure
meperidine
G6PD EXACERBATION
really any drug, but sulfas and primaquine
DRUG INDUCED LUPUS
hydralazine, procainamide
MALIGNANT HYPERTHERMIA
HALOthane
naion
PDE-5 inhibitors
ototoxic
PDE-5 inhibitors, and Ags
neural tube defects
mom's on carbamazepine, valproic acid
ebstein's anomaly caused by
mom's on lithium
serum proteins can spew
easily removed from albumin (sulfonamides, phenybutazone, coumadin, sulfonylureas)
one pharmaceutical brings about rapid liver metabolism
OCP, phenytoin, barbituates, alcohol, rifampin, levadopa, methadone
some pharmaceutical classes inhibit drug catabolism
sulfonamides, phenylbutazone, chloramphenicol, isoniazid, dicumarcol, cimetidine
some pharmaceuticals plus urate stop transporters
sulfonamides probencid pencillin uric acid salicylates thiazides