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25 Cards in this Set
- Front
- Back
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Most common inherited bleeding disorder is?
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Von willebrands
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Most common acquired bleeding disorder is?
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vit k deficiency
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What are the key features of von willebrand disease
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lack of factor 8-R
aPTT prolonged, bleeding time prolonged |
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what are the key features of hemophilia a?
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lack of factor 8
aPTT prolonged normal bleeding time |
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what are the features of hemophilia b?
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lack of factor 9
aPTT prolonged normal bleeding time |
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vit k defiency key features?
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PT prolonged
fat malabsorption antibiotics (dminished gut flora) coumadin therapy |
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What are key feature of idiopathic thrombocytic purpura
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immune mediated
childrean: acute, after viral infect adults: often chronic |
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What are key features of TTP?
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young women
microthrombi fragmented RBCs (helmet cells) |
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bleeding time depends on?
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platelet function
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PT time depends on?
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extrinsic pathway plus common
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aPTT depends on?
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intrinsic pathway plus common
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TT (bleeding) depends on
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common pathway
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key features of spherocytosis?
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autosomal dominant
defective spectrin splenomegaly |
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g6pd defiency key features
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hemolysis during oxidative stress
so..viral infections, fava beans, sulfa drugs, nitrofurantoin, quinine heinz bodies present |
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sickle cell key features?
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vaso-occlusive crisis, sequestration crisis (swollen spleen)
autosplenectomy aplastic crisis worsened by HYPOXIA, DEHYDRATION, ACIDOSIS |
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key features of alpha thalassemias
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HBH beta 4
common in SE ASIA hypochromic cells, TARGET CELLS Hb Bart (gamma 4) hydrops fetalis |
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key features of beta thalassemias
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HbA2 (alpha 2 beta 2) and HbF (alpha 2 and gamma 2)
common in Meditteraen and US, hypochromic and target cells |
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whats the difference between immune mediated anemias with warm antibodies and cold antibodies
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cold antibodies are on peripheral anemias, caused by IgM(minnesota) mycoplasma pneumo, mononucleosis, and lymphoma
warm IgG caused by drugs, malignancies, SLE |
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direct coombs test detects what?
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cell bound antibodies, mix rbcs with anti-IgG
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indirect coombs test measures
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free antibodies
mix pts plasma with normal RBCs |
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key features of megaloblastic anemia
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HYPOchromic, macrocytic
hypersegmented neutrophils if neuro symptoms, then b12 def, if none then consider folate |
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key features of iron defiency anemia
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HYPOchromic, MICROcytic RBCs
chronic blood loss, if elderly consider malignancy, esp right sided colon cancer and FOB positive |
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key features of aplastic anemia aka BM failure
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viral infections
toxins drugs- alkylating agents, chloramphenicol |
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plummer vinson sydrome triad?
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IDA
atrophic glossitis (esophagitis) esophageal webs (dysphagia) |
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key features of fanconi anemia
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autosomal recessive
hypoplastic thumbs absent radii aplastic anemia |
