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29 Cards in this Set
- Front
- Back
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Impairs viral uncoating. Treat Influence A, but only effective within 48 hours of sx onset
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Amantadine
Rimantadine works similary. No reccommended anymore |
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M.O.A: Inhibits viral RNA translation, induces MHC-1 expressuin.
DOC for chronic HBV and Chronic HCV What else can this drug used in treatment of? |
Interferon
Treat Hairy cell leukemia |
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MOA: looks like GTP, involved in transcription process and ultimately blocks viral mRNA synthesis.
DOC for chronic HCV |
Ribavirin
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Standard therapy for HCV
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peg-interferon alpha plus ribavirin
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MOA: gets incorporated into DNA causing inhibition of DNA polymerase as well as premature DNA chain termination in the virus. 'replication inhibitor'
Needs thymidine kinase in the virus for this drug to work on it |
Acyclovir
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Acyclovir is DOC for
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HSV-1
HSV-2 VZV EBV |
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Can you treat CMV with Acyclovir?
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No. It does not thymidine kinase
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What is the difference between acyclovir and valacyclovir?
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Valacyclovir has longer half life
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Vidarabine MOA and DOC for?
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imitates ATP, becomes incorporated into DNA and inhibitis DNA synthesis.
Used for herepes encephalitis and VZV (chickenpox or herpes zoster) in immunocompromised patients. |
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Which drug in ointment form is the second line DOC for herpes keratitis?
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Vidarabine
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What do you use to treat CMV?
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Ganciclovir.
Does not require thymidine kinase to work. AEs: bone marrow suppression, neutropenia and aplastic anemia |
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NRTIs
MOA and DOC for |
necleoside reverse transcriptase inhibitors- become converted to nucleotides and inhibit viral DNA synthesis.
DOC for HIV |
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Lamivudine is an alternative to what in treatment of HBV infections?
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Peg-interferon alpha
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AZT or zidovudine
didanosine stavudine lamivudine |
examples of NRTIs
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saquinavir
ritonavir indinavir nelfinavir fasamprenavir |
Protease inhibitors
MOA: inhibit cleavage of the "gaint" protein (gag-pol-env) that HIV must cut apart in order to have the functional components of that protein |
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NNRTIs
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directly inhibit reverse transcriptase.
examples: nevirapine, delavirdine, efavirenz |
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Enfuvirtide
MOA |
binds to gp41 and prevents viral fusion with the cells membrane
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high risk of bacterial pneumonia with what HIV drug?
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Enfuvirtide
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Raltegravir
MOA and used for? |
Integrade inhibitor- prevents integration and insertion of HIV DNA into human DNA
used for HIV |
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Maraviroc
MOA |
block the CCR5 co-receptor on WBC targeted by HIV.
also approved for CCR5-tropic HIV-1 (R5 virus) it is hepatotoxic |
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Zanamivir and oseltamivir
Treat? |
work to inhibit influenza virus neuraminidase.
zaminivir can cause bronchospasm. Treatment of influenza A and B |
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What drug is used for prophylax of influenza A and B?
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Neuraminidase inhibitors
Zanaminir and oseltamivir |
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MOA: direct inhibitor of both DNA polymerase and reverse transcriptase.
hint : alternative to ganciclovir for CMV |
Forcarnet
also for acyclovir and ganciclovir resistant VZV and HSV |
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toxicity associated with Foscarnet
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nephrotoxicty
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toxicity associated with CCR5 antagonist
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hepatotoxicty
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DOC for CMV retinitis
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ganciclovir an valganciclovir
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DOC for herpes keratitis.
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Trifluridine ; inhibits viral DNA synthesis
solution form |
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DOC for small pox. severe adenovirus infection and alternate to CMV retinitis
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Cidofovir
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Why is cidofovir given with probenecid?
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Cidofovir is extremely nephrotoxic-caused fanconi symdrome (PCT destruction)
Given with probenecid to minimize dosasge. |
