Bbc Segment 3

Front 1

describe MOA of amantidine

Back 1

amantidine binds to influenza A;s M2 protein...we think M2 docks flu A to cell lysosomes leading to digestion of capsid and release of nucleic acid. so since M2 is blocked, the virus cannot attach to lysosomes and uncoat itself

Front 2

MOA of acyclovir

Back 2

acyclovir is a DNA SYNTH inhibitor
it is tri phosphorylated by VIRAL specific thymidine kinase (found in HSV, VZV, EBV)...to look like FTP and incorporated into viral DNA

Front 3

name 5 protease inhibitors

Back 3

saquinavir ritonavir indinavir, nelfinavir, fosamprenavir

Front 4

MOA and use of trifluridine

Back 4

mimics TTP, so incorporated into viral DNA and INHIBIT VIRAL DNA SYNTH
DOC for herpes keratitis (2nd choic is vidarabine)

Front 5

what's the standard therapy for chronic HCV?

Back 5

pegylated INF alpha + ribavirin

pegylated means does not require daily dosing

Front 6

name the 4 gastritis(es)

Back 6

Acute erosive - alochol, nsaids, stress
Chronic type A - Fundal - autoimmune, pernicious anemia, Achlorhydria
Chronic type B -Antral - h. pylori
Menetrier's - Thickened mucosa

Front 7

patient presents with weight loss, arthritis and anemia

Cause? tx?

Back 7

Whipple dz. - tropheryma whippeli
PAS positive macrophages in mucosa
Tx = penicillin or tetracycline

Front 8

Risk factors for cholelithiasis

Back 8

Fat, forty, female, fertile

Front 9

list the main drugs that cause liver dz 6+1

Back 9

INH, INF, imidazoles, statins, neviripine, valproate, griseo

Front 10

list the main drugs that cause BM dz

Back 10

chemo drugs, INF, zidovudine, ganciclovir, carbamezapine, chloramphenicol, flucytosine

Front 11

list the main drugs that cause nephrotox

Back 11

cyclosporine, NSAIDS, aminoglycosides, Amphoteracin B, foscarnet, codifovir

Front 12

MOA of imidizoles and tox?

Back 12

MOA - inhibit fungal p450 system - stops formation of ergosterol from ianosterol. cell membrane death

Front 13

MOA of AmpB

Back 13

binds ergosterols in membrane

Front 14

MOA of griseofulvin

Back 14

stops microtubules and mitotic spindles.