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49 Cards in this Set
- Front
- Back
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These drugs are easily displaced from albumin
(4 of them) |
Sulfonamides, Phenylbutazone, Coumadin, Sulfonylureas
Serum Proteins Can Spew |
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Drugs that induce P450
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OCP, Phenytoin, Barbiturates, Alcohol, Rifampin, Levodopa, Methadone
One Pharmaceutical Brings About Rapid Liver Metabolism |
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Drugs that Inhibit p450
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Sulfonamides, phenylbutzaone, chloramphenicol, isoniazid, dicumarol, cimetidine
Some pharmaceutical classes inhibit drug catabolism |
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Drugs that compete for renal transporters
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Sulfonamides, probenecid, PCN, urate (uric acid), salicyclates, thiazides
Some Pharmaceuticals Plus Urate Stop Transporters |
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Phenylbutazone....Use, interaction with albumin, interaction with p450?
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Phenylbutazone is an analgesic and an anti inflammatory
Used for arthritis and gout easily displaced from albumin inhibits P450 |
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Dicumarol.....what is it? how does it interact with p450?
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Dicumarol is an anticoagulant (like warfarin/coumadin)
inhibits p450 |
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What kind of necrosis do you see in TB? what does it resemble
is this reversible or irreversible |
casseous necrosis - cottage cheese
irreversible |
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what is the difference between primary and secondary intention wound repair?
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primary - edges are surgically attached - can have wound contraction
2ndary - wound edges not attached - granulation tissue |
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what inflammatory mediator(s) cause exudation?
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histamine and bradykinin
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what aspect of inflammation are prostaglandins involved in ?
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Fever, Vasodilation, and pain
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what does INF gamma do
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activate macrophages
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what disease results from mutation of IL2 receptor
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Severe combined immune deficiency
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what triggers the compliment system? Classical and alternative
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classical - antigen-ab complexes
alternate - yeast and bacterial cell walls or Endotoxin, and cobra venom |
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what is the autoantibody in drug induced lupus?
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anti - histone
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what is serum sickness?
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type III Hypersensitivity - usually from drugs.
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What is the oncogene in colon carcinoma
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ras gene
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Most common primary site of metastatic bone cancer?
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breast>lung
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MOA of FQs
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inhibit bacterial topoisomerase = bacteria can't replicate
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Rifampin is DOC for this?
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rifampin is DOC for contact prophylaxis of meningococcal meningitis.....(Also used in TB Tx)
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Inheritance patterns of lysosomal storage dz's
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autosomal recessive, except fabry and hunters - x linked.
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which autosomal dominant dz causes hemolytic anemia
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spherocytosis
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What inherited dz presents with self mutiliation and gout?
Pattern? |
Lesch Nyhan syndrome - x linked
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Chromosomal abberation of retinoblastoma
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partial deletion of 13q
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What is HLA b27 associated with
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akylosing spondylitis
Ulcerative collitis Reiters syndrome |
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Most common solid malignancy outside of the CNS
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Neuroblastoma
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what give you a false positive VDRL? What is VDRL sensitive for?
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SLE
normally for syphilis |
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What is the problem in diffuse scleroderma?
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anti scl 70 Autoantibodies
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t cell ratio
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cd4:cd8 = 2:1
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acute phase response?
occurs where? what simulates and what is released? |
IL1, IL6 and TNFa induce liver to produce acute phase pr's.
CRP, serum amyloid, complement proteins, fibrinogen, prothrombin, plus others |
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autoantibody in sjogrens
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anti ss ro and anti ss la
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presentation of polyarteritis nodosa
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TETRAD:
fever, abdominal pain, hypertension, renal disease (NOT glom nephritis) |
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marker for Stem cells
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CD 34
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treatment for cyanide poisoning?
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amyl nitrate
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Use and MOA of hydralazine
Important side effect? |
vascular smooth muscle relaxation - increases arteriolar dilation - used for HTN.
Drug induced lupus - along with procainamide and INH |
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MOA of quinolones? Suffix?
Side effects? |
Inhibits topoisomerase - inhibits bacterial use of own DNA - floxacins
Tendon rupture, QT prolongation (contra'd w/ other QT prolongating drugs - azoles, NNRTIs, protease inhibitors, nicardipine, TCAs, amiodarone, procainamide, some ssris, some anti psychs) |
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what is polymyxin
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antipseudomonal antibiotic, topical only
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Person has recurrent baccterial infections, thrombocytopenia, and eczema
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wiskott aldrich, x linked recessive
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young woman presents with microthrombi and helmet cells?
Dz? and genetics? |
Thrombotic thrombocytopenic purpura
adamts13 |
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Describe the 2 bad Alpha thalassemias
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3 gene alpha thal = HbH - Bx4
hypochromic cells, and target cells 4 gene alpha thal -> hydrops fetalis |
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what diseases cause immune mediated hemolytic anemias in the cold.
what kind of Ab |
mycoplasma pneumoniae
lymphoma mononucleosis 0-4 degress celcius - IgM |
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Person presents with
anemia esophageal webs atriphic glossitis |
plummer vinson syndrome
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person presents with
hypoplastic thumbs absent radius bone aplastic anemia |
Fanconi anemia
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what do you see pappenheimer bodies in?
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siderocytes - Iron overload
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what 4 things do you see target cells in?
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HALT
HbC disease asplenia Liver Disease Thalasemia |
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what is felty syndrome?
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Immune mediated destruction of neutrophils
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what change in WBC count do we see in TB?
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increase lymphocytes and monocytes
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yound adult presents with night sweats, Fever, and splenomegaly
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CML
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Where does IL 7 come from and what does it do?
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Comes from Bone marrow cells
stimulates Proliferation of B and T cells. |
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patient present with
hemoptysis, hematuria, palpable purpura with Glom nephritis |
microscopic polyangiitis
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