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32 Cards in this Set
- Front
- Back
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PG arise from what??
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Phospholipids that interact with phospholipase A2. This makes arachodonic acid. Arachodonic acid than interacts with COX to make PG
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What are the 3 function of PG
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Vasodialation, fever, pain
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What is the job of NO and who makes it?
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Vasodilation and made by endothelium
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What is the job of IL-1?? Who makes it
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Induce fever. Made by macrophages
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What is the function of histamine?
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Exudation (leaky bv)
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What drug inhibits the production of bradykinin
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ACE inhibitors
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What are the 3 functions of bradykinin
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Vasodialation, pain, exudation
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What are 2 drugs that should be avoided in asthmatics
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Beta blockers and ACE inhibitors
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What is the function of C5a
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Chemotaxis
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What is the function of IL 8
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Chemotaxis
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What is the function of C3b
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Assist in opsonization. Is not needed for phagocytosis but enhances it.
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What activates CD 4 cells??
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IL 1 from macrophages
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What do CD 4 cells activate??
IL 2 IL 4 and 5 |
B cells, NK cells, and CD 8
B cells |
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What does IL 6 and 8 come from and what does it activate??
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Comes from monocytes and activates b cells.
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What activates monocytes?
Where does this come from? What does a monocytes become?? |
IFN gamma
B-cells, NK cells, CD 4 and CD 8 Macrophages |
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What kind of cells do NK cells target?
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Bacteria, fungi, and protozoans
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What do b cells turn into?
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Plasma cells to secrete ABs
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Where does CSF come from and what does it do??
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From NK cells, b cells, and CD 8. Goes to BM and stimulates BM to make and release WBCs.
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What are MHC
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Major histocapatability complex
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On what chromosome is MHC located?
What are its genes called?? |
Chrom 6
Called human leukocyte antigen (HLA). |
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What are the two classes of HLA and where are they found??
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Class 1: HLA-A,B, C. Found on all nucleated cells but RBC
Class 2: HLA- DQ DR DP. Found on all antigen presenting cells (APC) |
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What is the function of class 2 HLAs??
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To allow the docking of CD 4 cells to APCs
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When someone is tissue type matched, what are they checking??
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Checking to make sure the donor and the recipient have similar class 1 HLA antigens.
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What 3 cytokines induce fever??
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IL 1, PG, and TNF alpha.
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What does endothelium secrete that causes proliferation of SM cells??
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PDGF
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What cytokines induce the acute phase response??
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TNF alpha, IL1, and PG
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What does the liver do in response to acute phase response??
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Production of CRP, complement proteins, amylases, fibrinogen, and prothrombin (clotting factor 2)
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What makes up the C3 convertase??
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C4a2a
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What makes up the MAC
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C5b6,7,8,9
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What makes up the alternate convertase??
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C3bBb
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What activates the classical complement pathway??
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AB complexes and C1
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What activates the alternative pathway??
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Endotoxins, cobra venom, polysaccharides
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