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7 Cards in this Set
- Front
- Back
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Drugs that inhibit P450 decrease the rate of metabolism of other drugs metabolized by P450. What does this do to the amount of active (effected) drug?
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There is a greater amount of active drug in the body (because it is not being metabolized by the now inhibited P450)
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Sulfonamides are:
what type of drug? induce/inhibit P450? have what action in the kidney? |
antibiotic / "sulfa drugs"
inhibit P450 compete for renal transporters |
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Salicylates are:
used as? have what action in the kidney? |
analgesics, antiseptic, disinfectant, & antipyretic
competes for renal transporters |
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"One Pharmaceutical Brings About Rapid Liver Metabolism"
stands for? |
OCP, Phenytoin, Barbiturates, Alcohol, Rifampin, Levodopa, Methadone - these are P450 inducers
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"Some Pharmaceutical Classes Inhibit Drug Catabolism" stands for?
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Sulfonamides, Phenylbutazone, Chloramphenicol, Isoniazid, Dicumarol, Cimetidine - drugs that inhibit P450
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"Some Pharmaceuticals Plus Urate Stop Transporters" stands for?
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Sulfonamides, Probenecid, Penicillin, Urate (uric acid), Salicylates, Thiazides - drugs that compete for renal transporters
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Fluoroquinolones should be avoided in patients with heart conditions. Why
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the combination of fluoroquinolone & antiarrhythmics may cause QT prolongation and therefore torsade de pointe
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