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24 Cards in this Set
- Front
- Back
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rubor
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redness
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dolor
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pain
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calor
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heat
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tumor
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swelling
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ring leader of the cytokines
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CD4 Tcell
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what would disappear if you lost the CD4 T cells
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IL-2, 4,5, decrease in INF-gamma, decrease B cells, CD8 T cells, NK cells, monocytes, and macrophages (which stimulate CD4-Tcells so you are really f-ed)
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Relate Bradykinin and ACE-I
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ACE-I inhibits ACE, which inhibits Bradykinin, so with ACE gone, Bradykinin increases and causes exudation, pain, and vasodilation (which is why ACE-I are antihypertensive drugs)
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what cell is affected in HIV
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CD4 Tcells
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region on chromosome 6
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MHC
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only on nucleated cells surfaces
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HLA class I
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present on antigen presenting cells
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HLA class II
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presents foreign substance that have been phagocytosed by antigen presenting cells
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HLA class II (the docking antigen)
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what do macs, T cells, B cells, and granulocytes (-phils) have in common
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all release INF-alpha for anti-viral affects (induce MHC-1 and inhibit mRNA translation of virus)
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what interleukon stimulates B cells that is not from the T cell?
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IL-7 (from bone marrow), also stimulates T cells (which is why it cant come from T cells)
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how is the fibroblast related to T, B cells, macs, and granulocytees
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it is anti-viral too BUT with release of INF beta & it is related to the T-cell because it releases IL-6 to stimulate B cells
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PDGF comes from what cells
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platelets and endothelial cells
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IL-1, IL-6, and TNF-alpha are all related how?
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they stimlate the ACUTE phase response of the immune system
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why would you monitor CRP in a pt with chronic immune disease
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it measures the stage of the disease (exacerbation or regression phase) increase in CRP = exacerbation and decrease in CRP means Sx will start regress
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what pathway is started by endotoxins
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alternate
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what pathways is started by antibody-antigen complexes
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classical
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what are the two convertases of C3
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4b2b (classical) and 3bBb (alternate)
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related 5a and 3a to shock (decrease blood pressure)
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if the complement pathway is activated, 3a and 5a are eventually released, they stimulate histamine, and histamine decrease the BP by vasodilation (ie: endotoxin can cause septic shock this way)
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how does C5a mediate inflammation
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chemotaxis (1.1)
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how does C3b mediate inflammation
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opsonization (1.1)
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