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8 Cards in this Set
- Front
- Back
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Acute tubular necrosis
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-characterized by death of cells that line the renal tubules; usually is focal of localized to distinct areas
-results in renal tubule dysfunction |
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-is the most common result of pre-renal acute failure, whereby too little blood is delivered to the kidney and too little fluid reaches the renal tubules
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ATN
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most common result of intrinsic acute renal failure
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ATN
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pathognomonic for ATN
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muddy brown casts on urinalysis
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some cases are associated with (2)
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hypoperfusion and destruction of renal tubules secondary to toxins
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Toxic Causes of ATN (7)
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free hemoglobin (from massive hemolysis)
myoglobin (from rhabdomyolysis) Ethylene glycol (radiator fluid) Aminoglycosides Amphotericin B Cisplatin Contrast Media |
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pts at risk for ATN
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should be pre-treated with IV fluids before receiving IV contrast
pts on metformin should have metformin withheld for 48hrsin advanced of contrast admin since if ATN occurs the metformin will not be excreted and serum levels of metformin will rise, resulting in potentially life-threatening lactic acidosis |
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Adressing ATN promptly; not addressed promptly
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most pts fully recover within 7-21 days;
it can cause chronic renal failure |
