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3 Cards in this Set
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Antihistamines:
MOA: work by blocking the histamine rec H1** --> DO NOT INHIBIT RELEASE OF HISTAMINE, only block the receptor Use: treat allergies, not good for tx of asthma ADRs: sedation, tinnitus, fatigue, dizziness, blurred vision, and anticholinergic effects BLACK BOX: do not take with MAO inhibitors*** |
H1 and H2 receptors decrease systemic BP by inducing decreased total peripheral resistance
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Diphenhydramine:
MOA: H1 blocker Use: Good local anesthetic and prevents motion sickness ADR: sedation |
Chlorpheniramine
MOA: H1 receptor antagonist Use: allergic rhinittis 1st generation antihistamine*** |
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Hydroxyzine
MOA: H1 receptor antagonist Use: prevent allergy associated puritis 1st gen antihistamine |
SECOND GENERATION antihistamine are:
1. Loratadine 2. Desloratadine 3. Fexofenadine MOA: Non sedating and cross the BBB. ADR: can predispose someone to an arrythmia when used with..... A) macrolides B) ketoconazole C) Itraconazole Contraindications: BPH, bladder obstruction, narrow angle glaucoma |
