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10 Cards in this Set
- Front
- Back
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What drug does the following?
binds to antithrombin III and enhances antithrombin's activity Antithrombin III nl binds and inhibits clotting factors 9,10,11, and 12, also inhibits factor 2 Major drug for pulm embolus, DVT, and MI It works in MINUTES*** |
Heparin
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What is the antidote for heparin OD?
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protamine sulfate
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What drug does the following?
inhibits promarily factor X efffects cannot be readily or rapidly reserved this DOES NOT** need to be monitored does not clear the body until at least 12 hrs from the last administration |
Low Molecular Weight Heparin:
Dalteparin Enoxaparin Tinzaparin |
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What is the Antidote to LMWH OD?
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None available
trick ya bitch |
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What drug does the following?
antagonizes vitamin K dependent factors 2,7,9,10 99% is bound to albumin and is easily displaced by sulfonamides takes 8-12 hrs to onset 2-5 days to onset Rx effect Major ARD is hemorrhage Contraindicated in PREGNANCY - bc it crosses the placenta |
Warfarin aka coumadin
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What is the antidote for coumadin OD?
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Vit K --> take 24 hrs to take effect
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What drug does the following?
polysaccharide binds to antithrombin and enhances antithrombin activity. uniquely activates antithrombin to selectively selectively inhibit ONLY FACTOR X(10)!!!! Antothrombin-dep selective factor X CAN BE USED IN PTS WITH HEPARIN HYPERSENSITIVITY*** |
Fondaparinux
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What is the antidote for Fondaparinux?
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again hahahaha aint one bitch!
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What drug does the following?
direct thrombin inhibitor bind to and block the active site on thrombin (factor II) only available IV administration regulated to use as a heparin substitute in hepamin intolerant pts |
Argatroban
Bivalirudin Lepirudin |
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Please detail the coagulation pathway
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Factors XII, XI, IX, converge on factor X
Factor X then activates Factor II (prothrombin to thrombin) Thrombin then activates factor I - fibrinogen Factor I activates factor Ia (fibrin which is insoluble) You can also have Tissue factor activate factor VII which can converge on factor X |
