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15 Cards in this Set
- Front
- Back
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What are 2 major limbic pathways involving glutamate?
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Projections of entorhinal cortex to hippocampus and dentate gyrus
Projections of the prefrontal cortex to the amygdala and the nucleus locus coeruleus |
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What is the function of GABA in the limbic system?
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Interneurons
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Function of dorsal raphe nucleus
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Regulation/modulation of mood
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What 2 types of pathways does the VTA give rise to?
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Mesocortical
Mesolimbic |
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What are the components of the reward system of the brain?
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Mesolimbic and mesocortical projections from the VTA
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What is the final common pathway for addictions?
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Projections of the VTA to the nucleus accumbens
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What does decreased activity in the nucleus accumbens result in?
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Loss of motivation (as seen in psychiatric disorders like depression)
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What do increased levels of monoamines result in?
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Increased feelings of well-being
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Increased serotonin levels
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Promotes feeling lf well being and sleep
Elevates the pain threshold Reduces aggression and compulsive behavior |
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Increased dopamine levels
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Increased feelings of well-being, aggression, alertness, sexual excitement
Reduced compulsive behavior |
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Increased NE levels
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Increased feelings of well being
Reduced compulsive behavior |
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Increased GABA levels
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Reduces anxiety and compulsive behavior
Elevates the pain threshold |
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Neuroleptics: general MOA? Use?
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Block dopamine receptors
Anti-psychotic |
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Benzodiazepines: MOA? effects?
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Bind GABA-A receptors, enhancing the normal inhibitory effect
Anti-anxiety, sedative, muscle relaxant, anti-convulsive properties |
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How could you inhibit the amygdala pharmacologically and why?
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Increas 5HT levels with SSRIs
Neurons of the dorsal raphe nucleus synapse onto GABAergic interneurons in the amygdala |
