Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/8

Click to flip

8 Cards in this Set

  • Front
  • Back
Opiod Actions
-CNS
-CVS
-EYE
-LUNGS
-GI
CNS
*Analgesia then euphoria
-sedation
-nausea
-anti-tussive

CVS
-Peripheral vasodilation

EYE
-Pupillary constriction

LUNGS
-respiratory depression

GI
-Antispasmodic
Opiod mechanisms
-Pathway Stimulated
-Receptors
-Mesolimbic pathway: reward

-Stimulates dopamine receptors: *MU, delta, and kappa
Signs of substance abuse
-Medical
-Behavior
-Laboratory
-infection, nasal/pulmonary, scars, drug requests

-poor school, work, family life

-urine, blood, hair
Opiod abuse pharm. treatment
-Detoxification
-Substitution
-Antagonist
-Relapse prevention
-Agonist, taper, and or clonidine

-methadone or buprenorphine

-naltrexone

-naltrexone
Benefits of Methadone
-administration
-pharmacokinetics
-pharmacodynamics
-Oral; no injection risks

-long acting; blocking dose possible

-stabilizing and normalizing effects: no highs or lows like heroin
Heroin
-Metabolism
-Solubility
-Time to onset
-Duration
-deacetylated to active metabolites
-lipid soluble; crosses BBB quickly
- Onset<1 minute
-Euphoria for 1-2 minutes, sedation for an hour, effects wear off in 3-5 hours
Opioid overdose
-Signs
-Treatment
-depressed respiration and constricted pupils in a drowsy/comatose patient

-Naloxone (opioid antagonist) injection
Buprenorphine
-Action
-Safety
-Benefits
-partial agonist of μ-opioid receptor

-ceiling affect increases the safety margin; lower abuse potential

-Prolonged receptor occupation blocks other opioid access; reduced craving and "blocking effect." less sedating