B&b Week 7: Hallucinogens

Front 1

LSD
-System involved
-Dosage
-Time course and halflife
-"Treatment"

Back 1

-Post-synaptic 5HT-2 receptor cascade
-dose>35 mcg is hallucinogenic; street dose is 50-300 mcg
-3 hour half life; onset in 30-60 minutes; lasts for 4-12 hours
-"Treatment" is a benzodiazepam and personal support

Front 2

LSD
CNS Effects
-4 with insight
-1 without insight

Back 2

Insight
1. Euphoria
2. Labile mood
3. Visual hallucinations
4. Synesthesias

No insight
-Ego fragmentation --> the bad trip

Front 3

Phencyclidine (PCP)
-5 Dissociative anesthesia effects

Back 3

1. analgesia
2. amnesia
3. suppresion of laryngeal reflexes
4. Little CV effect
5. Little muscle relaxation

Front 4

Phencyclidine (PCP)
-Main receptor involved
-5 other receptors involved

Back 4

* NMDA-glu-R antagonist

Also:
-Presynaptic DA and 5HT receptors
-Sigma receptor
-K+ and Na+ channel receptors

Front 5

Phencyclidine (PCP
-Dose
-Route of administration
-Time to onset
-Time to Recovery

Back 5

-5 mg dose

-Usually smoked in laced marijuana or parsley cigarettes

-5 minute onset

-24 to 48 hours to recovery

Front 6

Phencyclidine (PCP)
CNS Effects at normal dose

Back 6

1. ETOH intoxication like effects
2. "Floating" euphoria
3. Nystagmus
4. Hand and feet numbness
5. Marked Time and space distortion
6. Body image/consistency distortions
7. Audio/visual hallucinations

Front 7

Phencyclidine (PCP)
Larger/overdose effects --> medical emergencies

Back 7

1. Succumb to coma
2. paranoia
3. hyperacusis
4. hostile behavior
5. muscle rigidity
6. excessive salivation with loss of gag reflex
7. high fever
8. Increased BP and HR

Front 8

Phencyclidine (PCP)
-Chronic use effects
-Detox period

Back 8

-dulled thinking and reflexes, loss of impulse control, lethargy and depression.

-no permanent damage, but dysfunction persists for 2-3 weeks after last dose

Front 9

Phencyclidine (PCP)
Treatment

Back 9

-Benzodiazapines for seizures
-Antipsychotics for psychosis
-Be very CAREFUL with physical restraints

Front 10

MDMA
-Dose
-4 known systemic effects

Back 10

-75 to 300 mg

-increased HR and BP; dry mouth, and bruxism

Front 11

MDMA
CNS Effects

Back 11

1. "loving Euphoria
2. Loss of self/other boundaries
3. Loss of inhibition
4. "Promotes Intimacy
5. Increased anxiety

Front 12

MDMA
-Cognitive effects
-Perceptual effects

Back 12

Cognitive
-decreased desire and cognitive ability

Perceptual
-Intensified visual perception with possible hallucination
-marked time distortion
-Space distortion