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12 Cards in this Set

  • Front
  • Back
-System involved
-Time course and halflife
-Post-synaptic 5HT-2 receptor cascade
-dose>35 mcg is hallucinogenic; street dose is 50-300 mcg
-3 hour half life; onset in 30-60 minutes; lasts for 4-12 hours
-"Treatment" is a benzodiazepam and personal support
CNS Effects
-4 with insight
-1 without insight
1. Euphoria
2. Labile mood
3. Visual hallucinations
4. Synesthesias

No insight
-Ego fragmentation --> the bad trip
Phencyclidine (PCP)
-5 Dissociative anesthesia effects
1. analgesia
2. amnesia
3. suppresion of laryngeal reflexes
4. Little CV effect
5. Little muscle relaxation
Phencyclidine (PCP)
-Main receptor involved
-5 other receptors involved
* NMDA-glu-R antagonist

-Presynaptic DA and 5HT receptors
-Sigma receptor
-K+ and Na+ channel receptors
Phencyclidine (PCP
-Route of administration
-Time to onset
-Time to Recovery
-5 mg dose

-Usually smoked in laced marijuana or parsley cigarettes

-5 minute onset

-24 to 48 hours to recovery
Phencyclidine (PCP)
CNS Effects at normal dose
1. ETOH intoxication like effects
2. "Floating" euphoria
3. Nystagmus
4. Hand and feet numbness
5. Marked Time and space distortion
6. Body image/consistency distortions
7. Audio/visual hallucinations
Phencyclidine (PCP)
Larger/overdose effects --> medical emergencies
1. Succumb to coma
2. paranoia
3. hyperacusis
4. hostile behavior
5. muscle rigidity
6. excessive salivation with loss of gag reflex
7. high fever
8. Increased BP and HR
Phencyclidine (PCP)
-Chronic use effects
-Detox period
-dulled thinking and reflexes, loss of impulse control, lethargy and depression.

-no permanent damage, but dysfunction persists for 2-3 weeks after last dose
Phencyclidine (PCP)
-Benzodiazapines for seizures
-Antipsychotics for psychosis
-Be very CAREFUL with physical restraints
-4 known systemic effects
-75 to 300 mg

-increased HR and BP; dry mouth, and bruxism
CNS Effects
1. "loving Euphoria
2. Loss of self/other boundaries
3. Loss of inhibition
4. "Promotes Intimacy
5. Increased anxiety
-Cognitive effects
-Perceptual effects
-decreased desire and cognitive ability

-Intensified visual perception with possible hallucination
-marked time distortion
-Space distortion