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11 Cards in this Set

  • Front
  • Back
CT Grading in TBI
Highly predictive of outcome

*Diffuse Injuries
-I: No swelling
-II: Minimal Swelling
-III: Cisterns Absent
-IV: Swelling and Shift

*Evacuated mass lesion
*Non-evacuated mass lesion
Epidemiology of TBI
Scoring Systems
Glasgow Coma Scale
-What is tested?
-high inter-observer reliability
-Motor, Verbal, Eye. Motor score is as accurate as the overall score
-Severe <or= 8
-Moderate 9-12
-Minor 13-15
Pre-hospital complications
All are secondary to the TBI and where treatment is currently targetted
-Hypoxia 45%
-Hypotension 30%
-Anemia 30%

-Any of these: 50%
Goals of treatment
-Continue resuscitation

-Prevent secondary injury by maintaining brain perfusion

-Obtain diagnosis of type of TBI with CT scan
Fluid percussion injury
Inertia model
Controlled cortical model
Molecular events
-acute necrosis ??and apoptosis??

-progressive cortical atrophy over 1 year from apoptotic events??

-PMN infiltrate and edema occurs in the acute posttraumatic period (3 days)
Plasticity in Hippocampus
progressive atrophy over 1 year...
-CA1 damage leading to epilepsy??

-Hylus damage leads to memory loss??
Neural regeneration in dentate gyrus
Physiological consequences of synaptic reorganization
Behavioral Recovery