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11 Cards in this Set
- Front
- Back
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CT Grading in TBI
-Predictability? -Grading |
Highly predictive of outcome
*Diffuse Injuries -I: No swelling -II: Minimal Swelling -III: Cisterns Absent -IV: Swelling and Shift *Evacuated mass lesion *Non-evacuated mass lesion |
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Epidemiology of TBI
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?
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Scoring Systems
Glasgow Coma Scale -Reliability -What is tested? -Grades |
GCS
-high inter-observer reliability -Motor, Verbal, Eye. Motor score is as accurate as the overall score -Severe <or= 8 -Moderate 9-12 -Minor 13-15 |
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Pre-hospital complications
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All are secondary to the TBI and where treatment is currently targetted
-Hypoxia 45% -Hypotension 30% -Anemia 30% -Any of these: 50% |
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Goals of treatment
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-Continue resuscitation
-Prevent secondary injury by maintaining brain perfusion -Obtain diagnosis of type of TBI with CT scan |
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Fluid percussion injury
Inertia model Controlled cortical model |
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Molecular events
-necrosis -apoptosis -inflammation |
-acute necrosis ??and apoptosis??
-progressive cortical atrophy over 1 year from apoptotic events?? -PMN infiltrate and edema occurs in the acute posttraumatic period (3 days) |
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Plasticity in Hippocampus
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progressive atrophy over 1 year...
-CA1 damage leading to epilepsy?? -Hylus damage leads to memory loss?? |
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Neural regeneration in dentate gyrus
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??
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Physiological consequences of synaptic reorganization
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??
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Behavioral Recovery
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???
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