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9 Cards in this Set
- Front
- Back
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Alzheimer's Disease
*Two hallmark lesions -Intra/Extra Cellular/Nuclear? -Composition? |
Senile plaques
-Extracellular -straight amyloid beta fibers -Neuritic and mature plaques are associated with dementia Neurofibrillary tangles -Intracellular (neurons) -Hyperphosphorylated paired helical Tau filaments; insoluble. |
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Distribution of NFT's and SP's in Alzheimer's Disease brain
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??
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Postmortem diagnosis of AD
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-Requires clinical history dementia
-Higher density of plaques and NFT's in the neocortex and limbic regions increases the likelihood that dementia was due to AD changes |
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Familial AD
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??
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Tauopathies
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??
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ALS/Motor Neuron Disease
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Cell loss/demyelination in the anterior horn/corticospinal tracts
Ubiquitin and TDP-43 Cytoplasmic inclusions in surviving motor neurons Spheroids: Neurofilaments Neurogenic group atrophy of muscle |
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Parkinson's Disease
-inclusions seens |
Lewy Bodies: neuronal cytoplasmic inclusions of Alpha-synuclein. Eosinophilic corse with a pale halo.
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Prion Disease
-Characteristic histopathology |
-Spongiform degeneration of cerebral and cerebellar cortex
-Severe neuronal loss -Severe astrocytosis -Protease resistant PrP |
