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9 Cards in this Set

  • Front
  • Back
Alzheimer's Disease
*Two hallmark lesions
-Intra/Extra Cellular/Nuclear?
Senile plaques
-straight amyloid beta fibers
-Neuritic and mature plaques are associated with dementia

Neurofibrillary tangles
-Intracellular (neurons)
-Hyperphosphorylated paired helical Tau filaments; insoluble.
Distribution of NFT's and SP's in Alzheimer's Disease brain
Postmortem diagnosis of AD
-Requires clinical history dementia

-Higher density of plaques and NFT's in the neocortex and limbic regions increases the likelihood that dementia was due to AD changes
Familial AD
ALS/Motor Neuron Disease
Cell loss/demyelination in the anterior horn/corticospinal tracts

Ubiquitin and TDP-43 Cytoplasmic inclusions in surviving motor neurons

Spheroids: Neurofilaments

Neurogenic group atrophy of muscle
Parkinson's Disease
-inclusions seens
Lewy Bodies: neuronal cytoplasmic inclusions of Alpha-synuclein. Eosinophilic corse with a pale halo.
Prion Disease
-Characteristic histopathology
-Spongiform degeneration of cerebral and cerebellar cortex

-Severe neuronal loss

-Severe astrocytosis

-Protease resistant PrP