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10 Cards in this Set
- Front
- Back
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Reserpine
-What does it do -Effect on direct agonists -Effect on indirect agonists -Effect on mixed agonists |
1. Blocks DA and NE entry into vesicles, leading to their metabolism by MAO
2. No effect 3. Eliminates indirect agonist action 4. Higher dose eliminates indirect agonist action |
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Alpha-1 Receptor
-Transmitter -Synaptic Location -Cellular Mechanism -Excitatory or Inhibitory -Tissue example |
1. NE and EPI
2. Postynaptic 3. Increase Ca2+ 4. Excitatory 5. Vasoconstriction |
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Alpha-2 Receptor
-Transmitter -Synaptic Location -Cellular Mechanism -Excitatory or Inhibitory -Tissue example |
1. NE, EPI
2. Presynaptic 3. Decrease cAMP 4. Inhibitory 5. Vasodilation when XS transmitter present |
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Beta-1 Receptor
-Transmitter -Synaptic Location -Cellular Mechanism -Excitatory or Inhibitory -Tissue example |
1. ISO>NE,EPI
2. Postsynaptic (Heart?) 3. Increased cAMP 4. Excitatory 5. Increased heart contraction |
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Beta-2 Receptor
-Transmitter -Synaptic Location -Cellular Mechanism -Excitatory or Inhibitory -Tissue example |
1. ISO, Epi
2. ???Presynaptic??? 3. Increased cAMP 4. ???Inhibitory??? 5. Smooth muscle relaxation |
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Dopamine 1/5 Receptors
-Transmitter -Synaptic Location -Cellular Mechanism -Excitatory or Inhibitory -Tissue example |
1. DA
2. Postsynaptic 3. Increase cAMP 4. Excitatory 5. Parathyroid, striatum |
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Dopamine 2/3/4 Receptors
-Transmitter -Synaptic Location -Cellular Mechanism -Excitatory or Inhibitory -Tissue example |
1. DA
2. Postsynaptic 3. Decrease cAMP 4. Inhibitory 5. Ant. pituitary, striatum |
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Monoamine Oxidase
1. Type A substrates 2. Tybe B substrates 3. Substrates of both |
1. 5-HT, NE
2. Tryptamine, phenylethylamine 3. DA, tyramine |
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Uptake 1
1. Affinity and Capacity 2. Transport Mechanism 3. Consequence of high affinity |
1.high affinity and low capacity
2. Na+ dependent carrier 3. potential false transmitter uptake |
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Catecholamine structure
1. Size of nitrogen group 2. Number of hyrdoxyls 3. Alpha-methylation |
1. Bigger means propensity for beta over alpha receptors
2. More mean better vesicle storage, but less CNS activity, and less oral bioavailability. 3. Prevents MAO degradation |
