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10 Cards in this Set

  • Front
  • Back
Reserpine
-What does it do
-Effect on direct agonists
-Effect on indirect agonists
-Effect on mixed agonists
1. Blocks DA and NE entry into vesicles, leading to their metabolism by MAO

2. No effect

3. Eliminates indirect agonist action

4. Higher dose eliminates indirect agonist action
Alpha-1 Receptor
-Transmitter
-Synaptic Location
-Cellular Mechanism
-Excitatory or Inhibitory
-Tissue example
1. NE and EPI

2. Postynaptic

3. Increase Ca2+

4. Excitatory

5. Vasoconstriction
Alpha-2 Receptor
-Transmitter
-Synaptic Location
-Cellular Mechanism
-Excitatory or Inhibitory
-Tissue example
1. NE, EPI

2. Presynaptic

3. Decrease cAMP

4. Inhibitory

5. Vasodilation when XS transmitter present
Beta-1 Receptor
-Transmitter
-Synaptic Location
-Cellular Mechanism
-Excitatory or Inhibitory
-Tissue example
1. ISO>NE,EPI

2. Postsynaptic (Heart?)

3. Increased cAMP

4. Excitatory

5. Increased heart contraction
Beta-2 Receptor
-Transmitter
-Synaptic Location
-Cellular Mechanism
-Excitatory or Inhibitory
-Tissue example
1. ISO, Epi

2. ???Presynaptic???

3. Increased cAMP

4. ???Inhibitory???

5. Smooth muscle relaxation
Dopamine 1/5 Receptors
-Transmitter
-Synaptic Location
-Cellular Mechanism
-Excitatory or Inhibitory
-Tissue example
1. DA

2. Postsynaptic

3. Increase cAMP

4. Excitatory

5. Parathyroid, striatum
Dopamine 2/3/4 Receptors
-Transmitter
-Synaptic Location
-Cellular Mechanism
-Excitatory or Inhibitory
-Tissue example
1. DA

2. Postsynaptic

3. Decrease cAMP

4. Inhibitory

5. Ant. pituitary, striatum
Monoamine Oxidase
1. Type A substrates
2. Tybe B substrates
3. Substrates of both
1. 5-HT, NE
2. Tryptamine, phenylethylamine
3. DA, tyramine
Uptake 1
1. Affinity and Capacity
2. Transport Mechanism
3. Consequence of high affinity
1.high affinity and low capacity

2. Na+ dependent carrier

3. potential false transmitter uptake
Catecholamine structure
1. Size of nitrogen group
2. Number of hyrdoxyls
3. Alpha-methylation
1. Bigger means propensity for beta over alpha receptors

2. More mean better vesicle storage, but less CNS activity, and less oral bioavailability.

3. Prevents MAO degradation