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38 Cards in this Set

  • Front
  • Back
Spatial Orientation requires
correctionforchangesinthe orientation of an object, but does not involve mental manipulation of parts within a figure
• Verylargeandconsistentmaleadvantage
healthy individuals first took test in their 50s 3 times. So we can see that with age spatial orientation goes
down, and men always did always better. In terms of how they performed,
ndividuals in their 60s, 70s and 80s perform relatively the same in all 3 trials except individuals in their 50s. In the 50s women catch up with males after mutliple trials. This is an example of
how there are sex differences, but the evironment can modify it through learning
Spatial Navigation: Different Strategies
Females use and remember landmarks.
Males use spatial cues and remember routes better
When females have high estrogen, their cognitive functioning
improves. But perform the wors on mental rotation test
for women what increases during menstruation
verbal fluency, fine motor control.
Shape of corpus callosum relates to
variety of cognitive abilities in women but not men regardless of whether those tasks show sex differences
Females need their corpus callosum to use both sides of their brain
The greater the corpus callosum in females, the better
naming, mental rotation, figure memory, verbal memory, and better verbal fluency. This did not correlate to men.
Emotional material memory had no differences in males and females. But there was a difference in the way they
processed emotional material when they first saw it (amygdala)
when putting pics of emotional scenes in front of men and women, women activation of left amygdala
he greater the activation the better they remember. For men is the right amygdala. Whats the importance of this? if men and women were put together and average them, there would be no activation in the amygdala, one could lead to the conclusion that the amygdala was not active, so sex differences have to be used to see the differences
Left amygdala activation in females relates to other areas like
Subgenual cortex, hypothalamus
– Brain areas attend to, and control, internal milieu (respiration)
in men, right amygdala activation relates to
Sensorimotor cortex, striatum, pulvinar
– Brain areas attend to, and act on, external environment
In women, defects following unilateral left VMPC damage, but mild or absent following right-sided damage
– may use
more analytic, verbally-mediated strategy
In men, severe defects following unilateral right VMPC damage, but not left-sided damage
– may use
more holistic, gestalt-type strategy
Testosterone Masculinizes and
Defeminizes
Animal Model of Early Androgen Exposure in Female Rats showed
Masculinized external genitalia
Congenital Adrenal Hyperplasia:
Exposure to excess androgens in utero in women
his study demonstrate that in the most sever form of congenintal adrenal hyperplesia, the normal male advantage in the hippocampal depedence maze is
not observed. Females take more time to solve this problem, but if female have some form of adrenal hyperplasia (extreme) they dont show disadvantage.
Androgen Insensitivity Syndrome:
Limited exposure to androgens in genetic XY males
No testosterone present
Demasculinizes and Feminizes
normally, men would show more rough play than women, but men with androgen insensitiviity syndrome
male show no differences.
Schizophrenia Course of the disease is more benign in
women compared to men. On average, females have:
schizophrenia Positive Symptoms: reflect
excess or distortion of normal functioning
- Hallucinations
- Delusions
- Disorganized language or thought processes
Negative Symptoms: reflect
reduction or loss of normal functioning
- Flat affect
- Decreased fluency and production in speech (alogia)
- Lack interest or motivation to engage in activities (avolition) or pleasure in activities (anhedonia)
when estradiol is low, symptoms of schizophrenia are
more severe, and when they are high (estradiol) they have less symptoms( day 20-22) of menstrual cycle)
Cycle-related changes in estradiol only predict
changes in positive symptoms
Depression characteristics
Sex Differences in Clinical Presentation
at around puberty, women start having greater rates of depression and spikes once
they hit menopause
sex-specific risk for depression because
only women go through menopause. When women go through menopause, estradiol falls, but large majority of women do not experience depression but some do.
Before it was thought that the mood changes in women would occur post menopausaly, but in fact it occurs while
hey are transitioning. Women with a history of PMS are more vulnerable to depression. Absolute levels of estrogen does not predict who will get depression , but the fluctuation.
for women who experienced depression during perimenopause, estrogen treatment
decreases their depressive symptoms. But estrogen treatment does nothing to depression that is not linked to hormonal transition
Alzheimer’s disease
Episodic Memory
A method to asses for alzheimers vulnerability, a neuroimaging scanner measuring the amount of glucose concentration in hippocampus while at rest, the more active the hippocampus
the least likelihood to develop alzheimers. The higher the education the more active the hippocampus so risk decreases
Young women, have more active and large hippocampus, which allows them to learn more verbal material, but as they transition to 40s
they lose this advantage-menopause.
women's brain on estrogen since early in menopause had an increase in
in activity in their hippocampus as they aged. putting women early in estrogen treatment can lead to hippocampus similar in activity to males.
women as opposed to males, remember stories better, words. But this memory decreases as we age, mostly because the
hippocampus is in charged of it.
Women who have their ovaries removed early in life have a 70% increase risk of
alzheimers disease, but if they are treated with estrogen there is no increase in risk.
Taking ovaries from women, verbal memory decreases, but if estrogen is given
decrease is prevented