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38 Cards in this Set
- Front
- Back
Spatial Orientation requires
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correctionforchangesinthe orientation of an object, but does not involve mental manipulation of parts within a figure
• Verylargeandconsistentmaleadvantage |
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healthy individuals first took test in their 50s 3 times. So we can see that with age spatial orientation goes
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down, and men always did always better. In terms of how they performed,
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ndividuals in their 60s, 70s and 80s perform relatively the same in all 3 trials except individuals in their 50s. In the 50s women catch up with males after mutliple trials. This is an example of
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how there are sex differences, but the evironment can modify it through learning
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Spatial Navigation: Different Strategies
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Females use and remember landmarks.
Males use spatial cues and remember routes better |
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When females have high estrogen, their cognitive functioning
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improves. But perform the wors on mental rotation test
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for women what increases during menstruation
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verbal fluency, fine motor control.
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Shape of corpus callosum relates to
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variety of cognitive abilities in women but not men regardless of whether those tasks show sex differences
Females need their corpus callosum to use both sides of their brain |
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The greater the corpus callosum in females, the better
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naming, mental rotation, figure memory, verbal memory, and better verbal fluency. This did not correlate to men.
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Emotional material memory had no differences in males and females. But there was a difference in the way they
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processed emotional material when they first saw it (amygdala)
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when putting pics of emotional scenes in front of men and women, women activation of left amygdala
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he greater the activation the better they remember. For men is the right amygdala. Whats the importance of this? if men and women were put together and average them, there would be no activation in the amygdala, one could lead to the conclusion that the amygdala was not active, so sex differences have to be used to see the differences
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Left amygdala activation in females relates to other areas like
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Subgenual cortex, hypothalamus
– Brain areas attend to, and control, internal milieu (respiration) |
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in men, right amygdala activation relates to
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Sensorimotor cortex, striatum, pulvinar
– Brain areas attend to, and act on, external environment |
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In women, defects following unilateral left VMPC damage, but mild or absent following right-sided damage
– may use |
more analytic, verbally-mediated strategy
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In men, severe defects following unilateral right VMPC damage, but not left-sided damage
– may use |
more holistic, gestalt-type strategy
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Testosterone Masculinizes and
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Defeminizes
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Animal Model of Early Androgen Exposure in Female Rats showed
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Masculinized external genitalia
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Congenital Adrenal Hyperplasia:
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Exposure to excess androgens in utero in women
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his study demonstrate that in the most sever form of congenintal adrenal hyperplesia, the normal male advantage in the hippocampal depedence maze is
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not observed. Females take more time to solve this problem, but if female have some form of adrenal hyperplasia (extreme) they dont show disadvantage.
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Androgen Insensitivity Syndrome:
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Limited exposure to androgens in genetic XY males
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No testosterone present
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Demasculinizes and Feminizes
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normally, men would show more rough play than women, but men with androgen insensitiviity syndrome
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male show no differences.
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Schizophrenia Course of the disease is more benign in
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women compared to men. On average, females have:
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schizophrenia Positive Symptoms: reflect
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excess or distortion of normal functioning
- Hallucinations - Delusions - Disorganized language or thought processes |
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Negative Symptoms: reflect
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reduction or loss of normal functioning
- Flat affect - Decreased fluency and production in speech (alogia) - Lack interest or motivation to engage in activities (avolition) or pleasure in activities (anhedonia) |
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when estradiol is low, symptoms of schizophrenia are
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more severe, and when they are high (estradiol) they have less symptoms( day 20-22) of menstrual cycle)
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Cycle-related changes in estradiol only predict
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changes in positive symptoms
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Depression characteristics
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Sex Differences in Clinical Presentation
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at around puberty, women start having greater rates of depression and spikes once
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they hit menopause
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sex-specific risk for depression because
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only women go through menopause. When women go through menopause, estradiol falls, but large majority of women do not experience depression but some do.
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Before it was thought that the mood changes in women would occur post menopausaly, but in fact it occurs while
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hey are transitioning. Women with a history of PMS are more vulnerable to depression. Absolute levels of estrogen does not predict who will get depression , but the fluctuation.
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for women who experienced depression during perimenopause, estrogen treatment
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decreases their depressive symptoms. But estrogen treatment does nothing to depression that is not linked to hormonal transition
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Alzheimer’s disease
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Episodic Memory
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A method to asses for alzheimers vulnerability, a neuroimaging scanner measuring the amount of glucose concentration in hippocampus while at rest, the more active the hippocampus
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the least likelihood to develop alzheimers. The higher the education the more active the hippocampus so risk decreases
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Young women, have more active and large hippocampus, which allows them to learn more verbal material, but as they transition to 40s
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they lose this advantage-menopause.
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women's brain on estrogen since early in menopause had an increase in
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in activity in their hippocampus as they aged. putting women early in estrogen treatment can lead to hippocampus similar in activity to males.
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women as opposed to males, remember stories better, words. But this memory decreases as we age, mostly because the
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hippocampus is in charged of it.
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Women who have their ovaries removed early in life have a 70% increase risk of
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alzheimers disease, but if they are treated with estrogen there is no increase in risk.
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Taking ovaries from women, verbal memory decreases, but if estrogen is given
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decrease is prevented
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