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39 Cards in this Set
- Front
- Back
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Lamotrigine: MOA |
Inactivates Na+ channels Inhibits release of excitatory AAs by acting on voltage-gated Ca2+ channels |
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Lamotrigine: Indication |
Simple/complex partial Generalized tonic-clonic Absence |
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Lamotrigine: Side effects |
Rash |
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Levetiracetam: MOA |
SV2A protein ligand Inhibits Ca2+-dependent excitatory AA transmitter release by interfering with with fusion of vesicles |
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Levetiracetam: Indication |
Simple/complex partial Myoclonic |
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Levetiracetam: Side effects |
Dizziness, somnolence, serious derm issues Possible behavior changes |
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Carbamazepine: MOA |
Inactivates Na+ channels --> reduces NT release Potentiates GABA responses |
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Carbamazepine: Indication |
Simple/complex partial Generalized tonic clonic |
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Carbamazepine: Side effects |
CNS side effects Aplastic anemia Rash |
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Oxacarbazepine: MOA |
Inactivates Na+ channel --> reduces NT release Potentiates GABA responses |
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Oxacarbazepine: Indication |
Simple/complex partial Generalized tonic-clonic |
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Oxacarbazepine: How is it different from Carbamazepine? |
Improved toxicity profile |
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Ethosuximide: MOA |
Inhibits T-type Ca2+ channel activity in thalamic neurons |
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Ethosuximide: Inidcations |
Absence seizures Myoclonic seizures |
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Ethosuximide: Side effects |
Gastric distress |
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Valproic Acid: MOA |
Inactivates Na+ channels --> reduces NT release Reduces T-type Ca2+ channel activity Increases GABA by inhibiting break down |
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Valproic Acid: Indications |
Generalized tonic-clonic Absence Myoclonic Complex partial |
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Valproic Acid: Side Effects |
Nausea, vomiting, other GI distress Hepatotoxicity |
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Diazepam: MOA |
Increases affinity of GABA for the GABAa receptor --> more inhibtion |
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Diazepam: Indication |
Status epilepticus |
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Phenytoin: MOA |
Inactivates Na+ channel --> blocks tetanic firing Reduces NT release |
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Phenytoin: Indications |
Simple/complex partial Generalized tonic-clonic Status epilepticus |
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Phenytoin: Toxicity |
Arrhythmia with rapid infusion Gingival hyperplasia Hirsutism Rash |
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Gabapentin: MOA |
Binds to voltage-gated Ca2+ channels --> decreases glutamate release |
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Gabapentin: Indication |
Adjuvant therapy for focal seizures w/ or w/o secondary generalizations Simple/complex partial Generalized tonic-clonic |
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Vigabatrin: MOA |
Inhibits GABA-T --> Increase GABA |
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Vigabatrin: Indication |
Adjuvant therapy for refractory complex partial infantile spasms |
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Vigabatrin: Side effects |
Potentially irreversible concentric visual field defect Drowsiness Dizziness Weight gain |
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Topiramate: MOA |
Na+ channel inactivation Inhibits glutamate receptors Enhances the actions of GABA |
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Topiramate: Indications |
Simple/complex partial Generalized tonic-clonic |
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Topiramate: Side effects |
Somnolence, fatigue, weight loss, nervousness, cognitive impairment |
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Zonisamide: MOA |
Inactivate Na+ channels Acts on T-type voltage gated Ca2+ channels |
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Zonisamide: Indications |
Adjuvant therapy for focal seizures Absence Myoclonic Infantile spasms |
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Zonisamide: Side effects |
Drowsiness, cognitive impairment, potentially serious skin rashes |
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Simple/Complex Partial Treatment |
Carbamazepine Phenytoin Gabapentin Topiramate Lamotrigine Levetiracetam |
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Generalize Tonic-Clonic Treatment |
Carbamazepine Phenytoin Valproic acid Gabapentin Topiramate Lamotrigine Lacosamide |
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Absence Treatment |
Ethosuximide Valproic acid Lamotrigine |
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Myoclonic Treatment |
Valproic acid Clonazepam Levetriacetam |
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Status epilepticus treatment |
Lorazepam or diazepam Phenytoin Phenobarbital |
