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17 Cards in this Set
- Front
- Back
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Which receptors use Gi 2nd messengers?
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M2, A2, D2 use Gi
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Which receptors use Gq 2nd messengers?
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H1, A1, V1, M1, M3 use Gq
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List the adrenergic receptor mechanisms
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A1: Gq, A2: Gi, B1: Gs, B2: Gs
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Gq molecular MOA
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Gq -> PIP2 -> DAG(Incr PKA) & IP3(Incr [Ca])
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Haldane Effect definition
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Deoxy Hb has greater affinity for CO2 & H+... in Lungs it releases CO2 and H+ [which shifts C.A. to produce CO2 + H2O]
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Heart changes seen with chronic high altitude
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RVH (as a response to hypoxic pulm vasoconstriction)
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Calculation of Physiological Dead Space
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Vd = TV x (PaCO2 -PeCO2)/PaCO2
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Bohr Effect definition
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Incr H+ from muscles -> Hb curve right shift
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Cellular changes seen in chronic high altitiude
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Incr mitochondrial
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Collapsing Pressure (of alveoli)
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2(tension)/radius (Laplace's law)
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Describe Conducting Zone
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Nose to terminal bronchioles, Anatomic Dead Space, walls lined with smooth muscle
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Describe Type II Pneumocytes
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Cuboidal cells, secrete surfactant, poliferate during lung damage (can -> Type I Pneumocytes)
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Where does Respiratory Zone begin?
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Respiratory Bronchioles
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Why is Hb saturation curve sigmoidal?
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Hb has Positive Cooperativity (4 O2 molecules)
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Describe funny channels
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Funny channels open at repolarization, causing slow Na+ influx, causing a slow depolarization (most Na channels open at hyperpolarization)
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What channels contribute to pacemaker potentials?
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Funny channels open at repolarization, causing slow Na+ influx, causing a slow depolarization (most Na channels open at hyperpolarization)
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Describes Phases of SA node AP
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SA Node AP: Phase 4 funny channels -> Phase 0 L-type Ca+ channels -> Phase 3 K+ channels depolarize
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