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279 Cards in this Set

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Drug
Chemicals used to diagnose, treat, or prevent disease.
Pharmacology
The study of drugs and their interactions with the body
Chemical Discription
The most detailedname for any drug.States its chemical composition and molecular structure. i.e. ethyl-1-methyl-4-phynylisonipecotate hydrochloride
Generic Name
usually suggested by the manufacturer and confirmed by the United States Adopted Name Council. Becomes the FDA official name when listed in the USP. Usually lower case.
USP
United States Pharmacopeia.The official standard for information about pharmaceuticals in the United States.
Brand Name
Also called trade name or proprietary name. a proper name and should be capitalized. Most mfg. register the name as a trademark.
What are the 4 main sources of drugs
Plants, animals, minerals and laboratory(synthetic)
What are the sources for drug information?
United States pharmacopeia (USP), Physicians Desk Reference (PDR), Drug Information, Monthly Prescribing Reference, AMA Drug Evaluation
What are the components of a drug profile
names, Classification, Mechanism of action, indications, pharmakinetics, side effects, contraindications, dosage, how supplied, special considerations
Components of a Drug name
Most frequently include the generic and trade names. Be aware of every name for each med.
Classification
The is the broad group to which the drug belongs.
mechanism of Action

pharmacodynamics
The way in which a drug causes is effects; its pharmacodynamics. The most important part of what we (EMS) are going to see.
Pharmacokinetics
How the drug is absorbed, distributed, and eliminated typically includes onset and duration of action. How it gets into the body
BEAD
Biotransformation
Elimination
Absorption
Distribution
Side Effects/Adverse Reaction
Untoward effect: causes serious side effects. Undesired effects: Mild side effects.
Routes of administration
How the drug is given
Contraindications
Conditions that make it inappropriate to give the drug when the drug is simply not indicated. a predictable harmful effect will occur is the drug is given in this situation. May coinside with side effects.
Dosage
The amount if the drug that should be given
Special Consideration
How the drug may affect pediatric, geriatric or pregnant patients.
pure Food and Drug Act of 1906
Enacted to improve the quality and labeling of drugs. Named the USP the official source for drug info.
Harrison Narcotic Act of 1914
Limited the indiscriminate use of addicting drugs by regulating the importation, manufacture, sale and use of opium, cocaine and their compounds or derivatives.
Federal Food Drug and Cosmetica Act of 1938
Empowered the FDA to enforce and set premarket safety standards for drugs.
Durham Humphry Admendments
AKA the prescription drug amendments. required pharmacists to have either a written or verbal prescription from a dr. to dispense certain drugs. Also created over the counter meds.
Comprehensive Drug Abuse Prevention and Control Act
AKA Controlled Substances Act. is the most recent majot federal legislation affecting drug sales and use. Repelled and replaced the Harrison Narcotic Act.
5 Schedules of Controlled Substances
Schedule 1
high Abuse potential, leads to severe dependence, no accepted medical indications. Heroine, LSD, mescaline
Schedule 2
High Abuse potential, may leads to severe dependence, accepted medical indications. ie.e. opium, cocaine, morphine, oxycodone, methadone, secorbarbital
Schedule 3
Less Abuse potential may lead to moderate or low physical dependence, accepted medical indications. i.e. vicodin, tylenol with codeine
Schedule 4
Low abuse potential limited dependence. Diazepam, lorazepam, phenobarbital
Schedule 5
lower abuse potential, limited dependence, accepted medical indications. opioids often for cough or diarrhea
drug laws and regulations
State, Local , and Federal.
assay
Test that determines tje amount and purity of a given chemical in a preparation in the laboratory
Bioequivalence
relative therapeutic effectiveness of shemically equivalent drugs
bioassay
test to ascertain a drugs availability in a biological model.
Drug Development Timeline
preclinical 1-3 years
Clinical Research 1-10 years (average 5)
NDA review 2 months to 7 years (average 24 months)
Post market Surveillance indefinite
6 Rights of medication Administration
Right Medication
Right Dose
Right Time
Right Route
Right Patient
Right Document
Dose Packaging
Medication packages contain a single dose for a single patient
Teratogenic Drug
medication that may deform or kill the fetus
FDA Pregnancy Categories
A: No demonstrated Risk to Fetus
B: No risk in Animals but no studies in Pregnant women
C: Use with Caution
D: Fetal Risk
X: DO NOT USE, NO BENEFIT TO MOTHER
Drug Free Availability
Proportion of a drug available in the body to cause either desired or undesired effects.
Broselow Tape
Used to calculate drug doseges in pediatric patients
Active transport
requires the use of energy to move a substace.
Carrier mediated diffusion or facilitated diffusion
process in which carrier proteins transport large molecules across the cell membrane
passive transport
movement of a substance without the use of energy
diffusion
movement of a solute from an area of higher concentration to an area of lower concentration
osmosis
movement of solvent in a solution from an area of lower concentration to and area of higher concentration.
Metabolism
The bodys breaking down of chemicals into different chemicals
biotransformation
special name given to the metabolism of drugs. Occurs in the Liver.
prodrug (parent drug)
medication that is not active when administered, but whose biotransformation converts it into active metabolites.
first- pass effect
the livers partial or complete inactivation of a drug before it reaches the systemic circulation
oxidation
the loss of hydrigen atoms or the acceptance of an oxygen atom, This increases the positive charge on the molecule
hydrolysis
the breakage of a chemical bond by adding water, or by incorporating a hydroxyl group into one fragment and a hydrogen ion into the other
enteral route
delivery of a medication through the gastrointestinal tract
parental route
delivery of a medication outside of the gi tract, typically using needles to inject medications onto the circulatory system
Types of enteral routes
Oral
orogastric/nasogastric (OG/NG)
sublingual(SL)
Buccal
Rectal
Types of Parental Routes
IV, ET, IO, Umbilical, IM, SQ, inhalation/Nebulized, Topical, Transdermal, Nasal, Instillation, Intradermal
Drug Forms (solid)
Pills-easy to swallow
Powders: powder form of tablet
Tablet- powder compressed
Suppositories- rectal or vaginal (mixed with wax)
capsul- gelatin filled with powder or tiny pills
Solutions
Most common liquid preparation. Generally water based; some may be oil based
Tinctures
Prepared using an alcohol extraction process; some alcohol usually remains in the final drug preparation
Suspensions
Preparations in which the solid does not dissolve inthe solvent; if left alone the solid portion will precipitate out.
Emulsions
Suspensions with an oily substance in the solvent; even when well mixed, globules of oil separate out of the solution
Spirits
Solution of a volatile drug in alcohol
Elixirs
Alcohol and water solvent, often with flavoring added to improve the taste
Syrups
Sugar, Water and drug solution
Types of Drug Actions
-Binding to a receptor site
-Changing the physical properties of cells
-Chemically combining with other chemicals
-altering a normal metabollic pathway
Receptor
Specialized protein that combines with a drug resulting in a biochemical effect.
Affinity
Force of attraction between a drug and a receptor
Efficacy
A drugs ability to cause the expected response
second messenger
Chemical that participates in complex cascading reactions that eventually cause a drugs desired effect
Down Regulation
binding of a drug or hormone to a target cell receptor that causes the number of receptors to decrease
Up regulation
a drug causes the formation of more receptors than normal
Agonist
drug that binds to a receptor and causes it to initiate the expected response
Antagonist
drug that binds to a receptor but does not cause it to initiate the expected response
partial agonist
drug that binds to a receptor and stimulates some of its effects but blocks others
competitive antagonism
one drug binds to a receptor and causes the expected effect while also blocking another drug from triggering the same receptor
noncompetitive antagonism
the binding of a antagonist causes a deformity of the binding site that prevents an agonist from fitting and binding
Irreversible Antagonism
a competitive antagonist permanently binds with a receptor site
iatrogenic
a disease or response induced by the actions of a care provider. (physician produced)
Drug response relationship
correlation of different amounts of a drug to clinical response
plasma level profile
describes the lengths of onset, duration, and termination of action as well as the drugs minimum effective concentration and toxic levels
Allergic Reaction
AKA hypersensitivity. Effects occurs as the drug in antigenic and activates the immune system
idiosyncracy
drug effect that is unique to the individual, different than seen or expected in the population than general
Cross Tolerance
tolerance for a drug that develops after administration of a different drug.
Tolerance
decreased response to the same amount of drug after repeated administration
tachyphylaxis
rapidly occuring tolerance to a drug, may occur after a single dose. (usually occurs with decongestant and bronchodilation agents)
cumulative effect
increased effectiveness when a drug is given in several doses
Drug Dependence
the patient becomes accustomed to the drugs presence in his body and will suffer from withdrawal symptoms upon its absence
Drug interaction
the effect of one drug alter the response to another
drug antagonism
the effects of one drug blocks the response to another
Summation
AKA Addictive effect. two drugs that both have the same effect are given together to get the same effect. 1+1=2
Synergism
two drugs that both have the same effect that are given together to produce a resonse greater than the sum of their individual responses. 1+1=3
Potentiation
One drug enhances the effect of another. i.e. phenergan enhances morphine
interference
The direct biochemical interaction between two drugs, one drug affects the pharmacology of another
onset of action
the time from administration until a medication reaches it minimum effective concentration
Minimum effective concentration
minimum level of a drug needed to cause a given effect
duration of action
length of time the amount of drug remains above its minimum effective concentration
termination of action
time from when the drug levels drops below its minimum effective concentration until it is eliminated from the body
therapeutic index (TI)
ratio of a drugs lethal dose (LD)for 50% of the population to its effective dose (ED) for 50% of the population.

LD50/ED50
biologic half-life
time the body takes to clear one half of a drug
Drug response factors
Age, body mass, sex, environment, time of admin, pathology, genetics, psychology
6 Rights of drug administration
right person
right drug
right dose
right time
right route
right documentation
percutaneous drug administration
drugs applied to and absorbed through the skin
transdermal
slow and steady rate
mucouse membrane admin
drugs absorbed through mucous membranes at moderate to rapid rate
Asepsis (Aseptic)
a condition free of pathogens
Local
limited to one area of the body
systemic
throughout the body
sterile
free of all forms of life
medically clean
careful handling to prevent contamination
disinfectant
cleansing agent that is toxic to living tissue. Never use on living tissue
antiseptic
cleansing agent that is not toxic to living tissue. used to clean living tissue
Routes of Administration
percutaneous
Pulmonary
Enteral
Paretal
Topical Medication
material applied to and absorbed through the skin or mucous membrane
Mucous Membrane Sites of administration
tongue, Cheek, Eye, Nose, Ear
Abbreviations for Eye drug administration
o.d.-right eye
o.s. - left eye
o.u. - both eyes
Aural Medication
Drugs administered through the mucous membrane of the ear and ear canal
Pulmonary Medication Mechanisms
Nebulizer
Metered dose inhaler
Endotracheal tube
Metered Dose Inhaler
Handheld device that produces a medication spray for inhalation
LEAN
Endotracheal Medications
Lidocaine
Epinephrine
Atropine
Naloxone
Emulsions
medications combined with a fat or oil emulsifier
Lozenge
solid form of medication that slowly dissolve in the mouth, permitting gradual swallowing
Hepatic Alteration
change in a medications chemical compoisition that occurs in the liver
Rectacl Administration
a good method. Bypasses the liver and absorption in more predictable
enema
a liquid bolus of medication that is injected into the rectum
bolus
concentrated mass of medication
Common rectal drugs
Valium, Versed, Narcan
Luer Adapter
Nipple at the end of a syringe
Luer Lock
Ability to screw syringe into place
Hypodermic Needle
hollow metal tube used with the syringe to administer medication
gauge
the size of a needle's diameter. the lower the number the larger the diameter
Kinds of parental drug containers
-glass ampules
- Single and multidose vials
- non constitutional syringe
- prefilled syringe
Ampule (Amp)
breakable glass vessel containing liquid medication
Vial
plastic or glass container with a self sealing top
non constituted drug vial/mix-o-vial
vial with two containers, one holding powdered medication and the other holding a liquid mixing solution
Prefilled/preloaded syringe
syringe packaged in a tamper proof container with the medication aready in the barrel
medicated solution
parental medication packaged in an IV bag and administered as an IV infusion
infusion
liquid medication delivered through a vein
Parenteral routes
ID, SQ, IM, IV, IO
intradermal (ID)
I.e. PPD. Deposit medication into the dermal layer of the skin. 15 degree angle
Subcutaneous (SQ)
the layer of loose connective tissue between the skin and the muscle. Pinch skin and go in at a 45 degree angle
IM sites
Deltoid, Dorsal Gluteal above pocket to avoid sciatic nerve, Vastus lateralis, Rectus Femoris
IV Access
AKA cannulation. surgical puncture of a vein to deliver medication or withdraw blood
Peripheral venous access
surgical puncture of a vein in the arm, leg or neck
Central Venous Access
Surgical puncture of the internal jugular, subclavian or femoral veins
Peripherally inserted central catheter
PICC line threaded into the central circulation via a peripheral site. Used for long term care.
Huber Needle
Angled needle that attaches to the ports of a PICC. Only needle that can be used with these ports
Colloid
intravenous solutions containing large proteins that cannot pass through capillary membranes
Crystalloid
IV solutions that contain electrolytes but lack the larger proteins associated with colloids
Crystalloid Classes
Isotonic
Hypertonic
hypotonic
Isotonic
state in which solutions on opposite sides of a semipermeable membrane are in equal concentration
Hypertonic
State in which a solution has a higher concentraton on one side of a semipermeable membrane than on the other side
Hypotonic
state in which a solution has a lower solute concentration on one side of a semipermeable membrane than on the other side.
Common Colloids
Plasma Protein Fraction (Plasmanate), Salt Poor Albumin, Dextran, Hespan
Microdrip
60 gtts per 1mL
macrodrip
10 gtts per 1mL
over the needle catheter/angiocatheter
semiflexible catheter enclosing a sharp metal stylet.
heparin lock
peripheral iv cannula with a distal medication port used for intermittent fluid or medication infusions.
saline lock
peripheral iv cannula with a distal medication port used for intermittent fluid or medication infusions. Saline is injected onto the device to maintaain its patency
Venous access device
surgicall y implanted port that permits repeated access to central venous circulation
huber needle
needle that has an opening in the side of the shaft instead of the tip
infusion controller
gravity flow device that regulates fluids passage through an electromechanical pump
extravascular
outside the vein
infusion pump
device that delivers fluids and medications under positive pressure
blood tube
glass container with color coded, self sealing rubber top
vacutainer
device that holds blood tubes
luer sampling needle
long, exposed needle that screws into the vacutainer and is inserted directly into the vein
Brand Name Drugs
Should be Capatalized, do not contain the (cemical composition or the ",USP" at the end
Official Name for Drugs
Not capatilized and contain the ",USP" at the end
Reference Materials, Sources for Drug information
USP (United States Pharmacopeia, PDA, Dring Information, Monthly Prescribing Reference, AMA Drug Evaluation
Physician Drug Reference (PDA)
A compilation of drug inserts, printed fact sheets that drug mfg. supply, includes 3 indices and a section containing photos of drugs
Drug Information
Published by the American Society of Health System Pharmacists. Contains an authoratative listing of monographs on every drug used in the USA
Monthly Prescribibg Reference
Designed to Assist physicians in prescribing medication and which are available to treat certain diseases
AMA Drug Evaluation
published by the American Medical Association
Plants (Source of Drugs)
Oldest Source. Digitalis
Why is there federal drug regulation?
To protect the public from adulterated and mislabeled drugs
Durham Humphry Amendment
Required pharmacists to have either a written or verbal presciption from a physician to dispense drugs
Schedule I
High Abuse Potential; may lead to severe dependence; no accepted medical indications; used for research, analysis or instruction only
Schedule II
High Abuse Potential; may lead to severe dependence; accepted medical indications
Schedule III
Less abuse potential than Schedule I and II; may lead to moderate or low physical dependence or high psychological dependence; accepted medical indications
Schedule IV
Low abuse potential compared to Schedule III; limited psychological and/or physical dependence; accepted medical indications
Schedule V
Lower abuse potential compared to Schedule IV; may lead to limited physical or psychological dependence; accepted medical indications
New Drug Development Phase I
To determine the drug's pharmacokinetics, toxicity and safe dose in humans. Carried out on limited population of volunteers. High risk drugs not carried out on humans
New Drug Development Phase II
Drug is tested on limited population of patients who have the disease it is intended to treat. Primary purpose is to find therapeutic drug level
New Drug Development Phase III
Main purpose is to refine the usual therapeutic dose and to collect data on side effects. Usually in a double blind study
New Drug Development Phase IV
Involves postmarket analysis during conditional approval. MFg. monitors its performance
FDA Classification of newly approved drugs
Method utilizes a number and a letter for each new drug in the IND phase or upon NDA review of the FDA.
IND Phase
Investigational New Drug. This phase is designated by the FDA if the results of animal testing are satisfactory
FDA Pregnancy Categories
A-no risk
B-no studies in pregnant woman(no risk in animals)
C-Adverse effects in animals=Use with caution
D-Fetal Risk Benefits could outweigh risks
X- Fetal Risk-risk outweighs any benefit to mother
Free Drug Availability
Proportion of a drug in the body to cause either desired or undesired effects
Extracellular Fluid in Neonates
80% (adults 50%-55%)
Pharmacokinetics
How a drug is absorbed, distributed, metabolized(biotransformed), and excreted; how drugs are transported into and out of the body
Pharmacodynamics
How a drug interacts with the body to cause its effects
Nubain (Nalbuphine)
Agonist-Antagonist. Stimulates some of the opioid agonists analgesic properties but partially blocks others such as respiratory depression.
What is the most common second messenger?
cAMP cyclic adenosine monophosphate
Naloxone (Narcan)
Antagonist. Binds to the opiate receptor, but will not initiate pain relief but does block narcotics and its response
mannitol (osmotrol)
increases urine output by increasing the bloods osmotic pull
Plasma Level Profile
Descibes the lengths of onset, duration, and termination of action as well as the drugs minimum effective concentration and toxic levels
Prototype
drug that best demonstrates the classes common properties and illustrates its particular characteristics
Central Nervous System
Brain and Spinal Cord
Peripheral nervous System
Broken down into Autonomic and Somatic
Somatic Nervous System
Controls Voluntary "Motor" functions
Autonomic Nervous System
Controls involuntary functions. Broken down into Sympathetic and Parasympathetic
Sympathestic Nervous System
Fight or Flight
Parasympathetic Nervous System
Feed or Breed
Morphine
Opioid Drug. Decreases cardiac preload and afterload. Analgesia, Euphoria, sedation. Useful in MI.
Non Opioid Analgesic
Aspirin, Buprofen, acetaminophen
opioid Antagonist
reverse effects of opioid drugs, such as narcan
Adjunct medication
enhances other drug effects. i.e. valium and versed.
Opioid Agonist Antagonist
displays both agonist and antagonist properties. i.e. Nubain and stadol
Antianxiety and hypnotic drugs
benzodiazepines and barbituates. Decreases response to stimuli by increasing effectiveness of GABA
GABA
Gamma-aminobutyric acid. Chief inhibitory neurotransmitter in the CNS.
Romazicon (flumazenil)
benzodiazeprine Antagonist(antianxiety, sedative/hypnotic) Reverses sedation
Antagrade
After administration of medications
MAOI
Antidepressent Medication
Monoamine oxidase inhibitor. DO NOT EAT CHEESE AND RED WINE (both contain tyramine)
EPS
Extrapyramidal Symptoms. Common side effects of antipsychotic medications. including muscle tremors and parkinsonism like effects
mimetic
to mimic and increase response
Autonomic ganglia
groups of autonomic nerve cells located outside the CNS
preganglionic nerves
Nerve fibers that extend from the CNS to the autonomic ganglia
postganglionic nerves
nerve fibers that extend from the autonomic ganglia to the target tissues
synapse
space between nerve cells
neurotransmitter
chemical messenger that conducts a nervous impulse across a synapse
neuron
nerve cell
cholinergic
pertaining to the neurotransmitter acetylcholine
adrenergic
pertaining to the neurotransmitter norepinephrine
Location of ganglia in the sympathetic nervous system
close to the spinal cord
Acetylcholine
Utilized in the preganglionic nerves of the sympathetic nervous system and in both the pre and postganglionic nerves of the parasympathetic nervous system.
Norepinephrine
is the postganglionic neurotransmitter of the sympathetic nervous system.
2 main types of ACh receptors
nicotinic and muscarinic
nicotinic
muscle. receptors are found at the neuromuscular junction and initiate contraction (somatic)
Muscarinic
(organ) found in many organs throughout the body responsible for promoting the parasympathetic response.
Parasympathomimetics
Cholinergics. drug or other substance that causes effects like those of the PNS
Parasympatholytics
Anticholinergic. drug or tother substance that blocks or inhibits the actions of the PNS
SLUDGE
Salivation, Lacrimation, Urination, Defecation, GAstric Motility, Emesis. Adverse effect of cholinergics.
Atropine
Muscarinic Cholinergic Antagonist.
sympathomimetic
drug or other substance that causes effects like those of the SNS. Adrenergic
sympatholytic
drug or other substance that blocks the actions of the SNS. Antiadrenergic.
Types of Sympathetic receptors
Adrenergic
-alpha 1
-alpha 2
-beta 1
-beta 2
Dopaminergic
Alpha 1
Response to stimuli
-vasoconstriction
-ejaculation
Alpha 2
Response to stimuli
-inhibits the continued release of NE
Beta 1
Response to stimuli
-increase HR
-increased conductivity
-increased automaticity
-increased contractility
Renin release
Beta 2
Response to stimuli
-Bronchodilation
-Vasodilation
-inhibits uterine contraction
-tremors
dopaminergic
response to stimuli
-vasodilation (increased blood flow) to the kidneys
Beta Blockers
Adrenergic Antagonists. used to treat tachcardia, hypertension, and angina. Causes bronchoconstriction and inhibited glycogenolysis. all end with olol.
fast potential
found in myocardial contractile tissue
Slow potential
found in av and Sa nodes
Antidysrhythmic
used to treat and prevent abnormal cardiac rhythms
Vaughn-Williams Claasifications

Sodium Channel Blockers
Class 1A-widening QRS, Prolonged QT
Class 1B-widening QRS, Prolonged QT (lidocaine)
Class 1C- Prolonged PR, Widening QRS
I- prolonged PR, widening QRS
Vaughn-Williams Classifications

Beta Blockers
Prolonged PR, bradycardia
Vaughn-Williams Classifications

Potassium Channel Blockers
prolonged QT

indication in VFIB causes initial release of NE. delayed repolarization.
VAugh-Williams Classifications

Calcium Channel Blockers
Prolonged PR, bradycardia (verapimil)

decrease SA and AV node automaticity
Vaughn-Williams Classifications
Misc.
Adenisine, prolonged PR, bradycardia
SA Node
The hearts dominant pace maker
Action potential
electrical impulses
AV Node
where conduction is delayed momentarily to give ventricals time to fill completely
Fast Potential
Occurs in the ventricular conduction system
Fast potential Cyclic activity Phases
Phase 0-depolarization (rapid influx of Na+ into the cell)
Phase 1- through 3- represent the repolarization. 1 k+ begins to leave the cell, 2 influx of Ca++ into the cell, 3 cessation of Ca++ and rapid efflux of K+.
phase 4 is resting membrane potential.
Antidystrythmic affects what stage?
Normally stage 4
Procardia
For hypertension, angina. Sytemic vasodilation, decreased blood pressure. Calcium Channel blocker. Only affects vascular smooth muscles of arterioles. Lower afterload
Frank Starlings effect
The greater the preload the greater the contractile force, the greater the afterload.
Loop Diuretic
profoundly affect circ. blood volume. Primary in treating CHF. Lasix. Decreased preload. Orthostatic Hpotension.
LDL
low density lipoprotein. Elevated levels causes coronary artery disease.
Beta 2 specific agents
treat asthma
Glucocorticoids
anti inflammatory properties. methylprednisolone
Leukotriene
mediators released from mast cells upon contact with allergens. contribute to inflammation and bronchoconstriction
Leukotriene Antagonist
block the synthesis. Zyflo, Accolate
Antitussive
medication that suppresses the stimulus to cough in the CNS
Expectorant
medication intended to increase the productivity of cough
Mucolytic
medication intended to make mucus more watery
H. Pylori
may promote ulcers
Adrenal Cortex
2 diseases associated with the adrenal cortex are cushings disease and addisons disease. Secrete androgens, glucocorticoids, mineralcorticoids
Secreted from the Beta Cells of the Pancreas Islets of Langerhans
Insulin:substance that decreases blood glucose levels. And Glucagon: substance that increases blood glucose levels
Oxytocin
Uterine Stimulant
Antineoplastic Agent
Drug used to treat cancer
Uricosuric Drugs
Used to treat Gout
Serum
Solution containing whole antibodies for a specific pathogen
Vaccine
Solution containing a modified pathogen that does nnot actually cause disease but still stimulates the development of antibodies specific to it
Portal Circulation
Hepatic Circulatory System
Endotracheal Medications
LEAN
Lidocaine, Epinephrine, Atropine, Naloxone
Most Common Rectal Meds
Valium, Versed, Narcan
extravasation
leakage of fluid or medication from the blood vessel that is commonly found with infiltration. Causes edema at iv site.