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57 Cards in this Set
- Front
- Back
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Barrier Defences
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Eyes
Respiratory Tract Skin Digestive Tract Genitourinary Tract |
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Immune Cells All Ultimately From:
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Pluripotent Haemopoietic Stem Cells
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Progenitor for Innate
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Myeloid Progenitor
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Progenitor for Adaptive
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Lymphoid Progenitor
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Lymphoid Progenitor Cells
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T Cells
B Cells NK Cells |
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Myeloid Progenitor Cells
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Neutrophils
Eosinophils Macrophages DC's Basophil Mast Cells |
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Granulocytes are
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Neutophils
Eosinophils Basophils |
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Most common myeloid?
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Neutrophils
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Granules of Neutrophils
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Primary
Secondary Tertiary |
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Primary Granules of Neutrophils have:
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Bactericidal Enzymes - Lysozyme
Myeloperoxidase Neutral Proteases Acid Hydrolases |
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Secondary Granules of Neutrophils have:
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All of primary's plus - Collagenase
Lactoferrin |
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Tertiary Granules of Neutrophils have:
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Geatinases - to degrade basement membranse of cells
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Granules of Eosinophils have:
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Cytokines
Prostaglandins Leukotrienes Proteolytic Enzymes Peroxidase Basic Protein Cationic Protein |
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Basic Protein (from Eosinophils) is to:
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Attack outer layers of an organism
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Cationic Protein (from Eosinophils) is to:
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Paralyse Nervous System of a parasite
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ADCC =
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Antibody Dependent Cell Mediated Cytotoxicity
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Eosinophils kill via:
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ADCC
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Eosinophils bind to:
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"IgE (parasite specific)
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Lobes of Granulocytes?
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Neutrophils are Multilobed
Eosinophils are Bilobed Basophils are Lobed |
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Granules of Basophils:
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Histamine
5-HT Heparin Prostaglandin |
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Receptors in Basophils
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Fc Receptors for IgE
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Mast Cells are similar to:
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Basophils in S + F
But distinct in lineage |
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Mast Cells Granules have:
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Histamine
Proteolytic Enzymes Cytokines |
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Role of Mast Cells:
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Sentinel - IgE Receptors
Allergic Response! |
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Mast cells also release:
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TNF
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Monocytes go to:
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Macrophages and DC's
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DC's are
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Professional APC's
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DC's in Epidermis Most Organs Lymph Spleen + Thymus Blood + Lymph Lymph Node Follicle
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Langerhans Interstitial DC's Interdigating DC's Circulating DC's Follicular DC's
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Percentage of Lymphocytes in WBCC?
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20-40%
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Lymphocytes hang out in:
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Blood Lymph Nodes
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4 Types of B Cells
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Naïve Plasma Memory T-Independent B Cells
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Sign of more mature B Cell
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Have Ab on Surface (IgM)
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T Cells Identified as have:
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CD3
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Subdivisions of CD3+ve cells
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CD4+ve (T Helper)
CD8+ve (Cytotoxic - T Killer) |
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Subdivisions of CD4+ve cells
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Th1
Th2 Th17 Th21 Treg |
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Th1 Secrete
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IFN Gamma
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Th2 Secrete
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IL 4
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Th17 Secrete
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IL 17
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Purpose of NK Cells -
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Is MHC 1 present? Kills cells where it isn't
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Lymphoid Organs Can Be:
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Primary or Secondary
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Primary Lymphoid Organ is where:
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Lymphocytes produce and mature
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Secondary Lymphoid Organ is where:
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Lymphocytes wait monitor activated
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Primary Lymphoid Organs are the
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Bone Marrow
Thymus |
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Secondary Lymphoid Organ are the:
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Lymph Nodes
Spleen |
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Lymph Node Structure:
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Cortex
Paracortex Medulla |
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Cortex of Lymph Node contains:
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Follicles (w/ B Cells Macrophages Follicular DC's)
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Paracortex of Lymph Node contains:
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"T Cells
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Paracortex of Lymph Node is where:
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T Cells are activated by Ag
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Medulla of Lymph Node contains:
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Plasma Cells
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Spleen gets it input from:
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Not Lymphatics! Just Blood!
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Blood enters spleen from
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Splenic Artery
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Spleens two main sections:
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Red Pulp
White Pulp |
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Red Pulp Purpose
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Remove Old RBC's
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White Pulp Purpose
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Active monitoring
Cells in PALS (Peri Arteriolar Lymphoid Sheath) |
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White Pulp Contains
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T Cells
B Cell Follicle Marginal Zone (with B Cells and Macrophages |
