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10 Cards in this Set
- Front
- Back
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Two key factors of the Adaptive Immune Response as part of the clonal selection theory that help B-Lymphocytes develop a vast repertoire.
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Diversity: Epitopes (also known as antigenic determinant) is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells.
Specificity: Ability to discriminate among different epitopes. |
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Do B-Cells acquire Discrimination between self and non-self?
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Yes.
Non-Self: The ability to respond to antigens that are "foreign", and preventing a response to those antigens that are part of self. |
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What parts of the Adaptive immune response do B-Cells acquire?
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Discrimination of self from non-self.
Memory. |
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Do B-Cells exhibit Memory?
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Yes.
The ability to recall previous contact with a particular antigen so the subsequent exposure leads to quicker, more effective immune response than the response to the first exposure. |
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How has the understanding of B-Cell differentiation been facilitated?
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By studying the different animals in which the early embryonic stages can be easily manipulated.
This has been particularly feasible in chicken and mice. The Bursa of Fabricius in birds is the site of antibody synthesis. |
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Is differentiation of B-Cells similar to the differentiation of T-Cells?
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Yes
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How are the stages of B-Cell differentiation defined?
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By the expression of different CD molecules.
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Precursors of B-Cell lineage are found in early fetal development, at which main site?
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The fetal liver.
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Later in fetal development and after birth, what is the primary site of B-Cell differentiation?
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Bone marrow.
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What is the primary lymphoid organ for B-Cell differentiation in adult humans and other mammals?
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Bone Marrow
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