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18 Cards in this Set
- Front
- Back
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Pharmacokinetics |
study of how the body interacts with drugs, including distribution, metabolism, and exretion |
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Absorption in elderly |
instruct patient to take antacids one hour before or four hours after other meds
antacids can alter absorption of some meds |
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metabolism |
may be significantly reduced in elderly
dosage adjustments may be necessary
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elimination |
many drugs can be therapeutic at a lower dose
start low and go slow |
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Pharmacology |
study of how drugs interact with the body |
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pharmacogenetics |
study of single-gene genetic variations in drug variations
goal is to understand the role that individual's genetic make up plays in how well a med works |
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pharmacogenetics vs pharmacogenomics |
pharmacogenetics begins with an unexpected drug response, then searches for a genetic cause
pharmacogenomics begins with looking for a genetic difference within a population that explain certain observed responses to a drug |
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Common adverse reactions to meds seen in elderly |
sedation memory loss dizziness depression confusion blurred vision urinary retention constipation dry mouth |
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drugs most likely to cause adverse effects in elderly |
benzos antipsyhcotics BB steroids cimetidine narcotics diuretics cholinergic agonists tricyclic antidepressants antipsychotics |
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adverse effects on balance and movement |
neuroleptics metronidazole phenytoin ASA aminoglycosides furosemide BB vasodilators metoclopramide |
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adverse effects on bone and supporting system |
steroids heparin lithium |
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Promoting drug safety in elderly |
elderly tend to take more OTC meds than any other group
Brown Bag..have pt bring all meds in to check |
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Cimetidine (tagamet) |
can in habit cytochrome P450 in liver thus prolonging effects of other meds |
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Decongestants |
antagonize the activity of antihypertensives |
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NSAIDS |
decrease renal blood flow thus further reeducating elimination of many drugs |
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Niacin |
may absorb other oral agents, reducing their absorbance across the gut wall |
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Laxatives |
may chelate other drugs so they can't be absorb may increase gut motility may reduce absorbance of some drugs |
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Calcium products |
may decrease absorbance of thyroid med
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