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10 Cards in this Set
- Front
- Back
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How are barbiturates administered?
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injectable
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What are some pros of using barbiturates?
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more rapid passage through phase 2
can use outside the clinic may be easier to use on fractious animals |
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What are the cons of using barbiturates?
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harder to control depth
recovery is variable because it depends on metabolism controlled substances |
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What is the MOA of barbiturates?
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bind to the barbiturate site on GABA receptors to potentiate GABA (increases inhibitory stimuli)
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What are the barbiturates?
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Thiopental
Pentobarbital Phenobarbital |
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Which barbiturates are short acting? Which are long acting?
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thiopental (ultra short), pentobarbital (short)
Phenobarbital (long) |
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What are the contraindications of barbiturates?
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cause tissue damage extravascularly
cause splenomegaly (don't use for splenectomy) don't eat meat of animals given barbiturates (esp Pentobarbital) don't use in pregnant animals duration of action longer in lean animals |
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Are barbiturates considered general anesthetics?
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NO
do not cause analgesia |
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Why is the duration of action longer in lean animals?
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barbiturates work by redistributing to muscle, then fat so there is nowhere to go in lean animals
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What are the systemic effects of barbiturates?
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CNS depression
respiratory depression (LOTS) muscle relaxation arrhythmia with thiopental CYP450 upregulation with phenobarbital |
