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16 Cards in this Set
- Front
- Back
What spectrum are tetracyclines?
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Broad range
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How do tetracyclines work?
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Inhibit binding of tRNA to mRNA complex
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How are tetracyclines given?
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Orally
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Tetracycline interact with calcium, iron, magnesium, aluminum, and zinc.
T or F |
True
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What is the elimination of the short and intermediate Tetracyclines?
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Kidneys
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What is the elimination of the long tetracyclines?
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Liver
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What are the adverse effects of tetracyclines?
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GI irritation
Yellow or brown discoloration of the teeth Suprainfection Photosensitivity Nenal Toxicity |
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What is the suprainfection associated with Tetracyclines?
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Antibiotic-associated Pseudomembranous colitis (diarrhea)
Fungi overgrowth |
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What spectrum are the Macrolides?
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Broad
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What is the prototype of the Macrolides?
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Erythromycin
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Erythromycin is the first choice for many infections and can be used as an alternative to penicillin.
T or F |
True
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What is the elimination of Erythromycin?
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Liver
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What are the adverse effects of erythromycin?
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GI effects
Liver Injury (erythromycin estolate- cholestatic hepatitis) QT Prolongation and Sudden Cardiac Death |
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What are the adverse effects of Clindamycin?
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Antibiotic-associated Pseudomembranous colitis
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What is an effective drug against VRE and MRSA?
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Linezolid
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What is the adverse effect of Linezolid?
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Reversible Mylosuppression
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