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16 Cards in this Set

  • Front
  • Back
What spectrum are tetracyclines?
Broad range
How do tetracyclines work?
Inhibit binding of tRNA to mRNA complex
How are tetracyclines given?
Orally
Tetracycline interact with calcium, iron, magnesium, aluminum, and zinc.
T or F
True
What is the elimination of the short and intermediate Tetracyclines?
Kidneys
What is the elimination of the long tetracyclines?
Liver
What are the adverse effects of tetracyclines?
GI irritation
Yellow or brown discoloration of the teeth
Suprainfection
Photosensitivity
Nenal Toxicity
What is the suprainfection associated with Tetracyclines?
Antibiotic-associated Pseudomembranous colitis (diarrhea)
Fungi overgrowth
What spectrum are the Macrolides?
Broad
What is the prototype of the Macrolides?
Erythromycin
Erythromycin is the first choice for many infections and can be used as an alternative to penicillin.
T or F
True
What is the elimination of Erythromycin?
Liver
What are the adverse effects of erythromycin?
GI effects
Liver Injury (erythromycin estolate- cholestatic hepatitis)
QT Prolongation and Sudden Cardiac Death
What are the adverse effects of Clindamycin?
Antibiotic-associated Pseudomembranous colitis
What is an effective drug against VRE and MRSA?
Linezolid
What is the adverse effect of Linezolid?
Reversible Mylosuppression