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13 Cards in this Set
- Front
- Back
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What are the protein synthesis inhibitors ?
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Tetracyclines
Macrolides Clindamycin Chloramphenicol Linezolid Dalfopristin Spectinomycin |
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Are these drugs bacteriocidal or static ?
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They are all bacteriostatic...they suppress growth and replication, but do not outright kill.
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In general, are drugs in this cateogry first or second line ?
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Second line...primarily because of emerging toxicity
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Tetracycline is the first line drug for which infections ?
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Rocky Mountain spotted fever (rickettsia)
H. pylori (ulcers) Bacillus anthracis (anthrax) Borrelia (Lyme disease) M.pnuemoniae |
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Which OTC supplements should not be taken with tetracyclines and why ?
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Tetracyclines form insoluble chelates with calcium, iron, magnesium, aluminum and zinc. They should not be administered with Ca supplements, milk, iron supplements, magnesium containing laxatives and most antacids
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Which two tetracyclines CAN be administered with food ?
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Doxicycline and minocycline
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Why should tetracyclines not be given to pregnant women?
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They can stain developing teeth and therefore should not be given to pregnant women and those under 8
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Which suprainfections can tetracyclines can cause and why ?
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Because they are broad spectrum, tetracyclines can cause AAPMC, and overgrowth of the mouth, pharynx, vagina or bowel with candidas
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Hepatitic toxicity is especially a concern for which patients taking tetracyclines ?
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pregnant and postpartum women and those with kidney impairment
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Which form of erythromycin is especially dangerous ?
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erythromycin estolate
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Which drug has an especially high incidence of AAPMC ?
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clindamycin
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Aplastic anemia and other serious blood dyscrasias can be caused by this drug...
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Chloramphenicol
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Why is linezolid an important drug ?
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because it can suppress multidrug resistant gram positive pathogens including VRE and MRSA.
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