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6 Cards in this Set
- Front
- Back
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in phages where is the viral ligand that interacts with the bacterial receptor?
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on the tail fibers
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during what phage in the lytic cycle is there no infectious phage detectable?
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the eclipse phage after injection of nucleic acid
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how can prophages increase the survival fitness of the host cell?
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can convert non-pathogenic bacterial strains into pathogenic ones, and confer phage repressor and super-infection exclusion
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what kind of toxin and phenotype do phages confer upon vibrio cholerae? E. coli? Clostridium botulinum? Corynebacterium diphtheriae? Streptococcus pyogenes?
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cholerae toxin (cholera). shigalike toxin (hemorrhagic diarrhea). botulinum toxin (food poisoning). diphtheria toxin (diphtheria). erythrogenic toxins (scarlet fever).
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advantages and disadvantages of bacteriophage as antibiotic replacement?
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adv: once it infects one cell it can quickly infect lotsa others. can evolve with bacs. infect only target bacteria. Dis: must know specefic bug you want to kill, phage elicits strong antibody response, can release large quantities of endotoxin from lysed bacterial cells, and most pharm co's have not invested in trials bc it is expensive.
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what types of vaccines can be made from phage?
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a phage display which will put a peptide on the surface of a phage and elicit a humoral immunity (B cells). DNA vaccine has DNA inserted into the phage and will elicit cell mediated immunity (T cell) upon phagocytosis of the phage. Note you can combine the two theoretically into a hybrid phage vaccine.
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