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16 Cards in this Set
- Front
- Back
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What 2 species will form a germ tube? How may they be differentiated?
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Candida albicans
C. stellatoidea C. albicans is sucrose positive, while C. stellatoidea is sucrose(-) |
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This differentiates pseudohyphae from true hyphae?
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constrictions between adjacent cells
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The most common example of dermatophytosis is -
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Ringworm
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What 3 genera comprise the deratophytes?
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Microsporum, Trichophyton, and Epidermiphyton
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In a lesion formed by ringworm would it be more beneficial to take a sample from the edge or from the center of the lesion?
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from the center
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This yeast is commonly associated with otitis externa-
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Malassezia pachydermatis
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The key membrane lipid in fungi is -
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ergosterol
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T/F Griseofulvin is active against a wide range of fungi
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False - Griseofulvin is only effective agains dermatophytes
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Where is griseofulvin concentrated?
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newli formed cells of skin, nails, and hair
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Griseofulvin prevents mitosis by interfereing with what?
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Mitotic spindle formation
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T/F Resistance to Griseofulvin is uncommon
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True
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Amphotericin B has ___________ action.
A) Fungistatic B) Fungicidal |
Fungistatic
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Amphotericin B toxicity is likely to be seen in
A) Liver B) Heart C) Lungs D) Kidney |
D) Kidney - nephrotoxicity
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Explain the 2 mechanisms of action of 5-FC (Flucytosine)
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1) Converted to 5-fluorouracil which replaces RNA in the cell
2) 5-FU converted to 5-fluorodeoxyuridine monophosphate which inhibitds thymidine producion neccesary for DNA synthesis. |
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Since 5-FU is the active form why is 5-FC (Fluocytosine) used.
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5-FU is not taken up by fungi and is toxic to mammalian cells
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Why are 5-FC and Amphotericin-B often used in combination?
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Less Amphotericin is neccesary and amphotericin makes the fungal cell wall more permeable to 5-FC
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