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32 Cards in this Set
- Front
- Back
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What are the characteristics of haemphilus?
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gram negaive rods - small
facultative anaerobes |
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What does haemphilus require to grow?
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X facor
V factor |
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What is X factor?
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one of 2 requirement for haemophilus to grow
heat stable protoporphyrin IX |
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What is V factor?
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one of 2 requirements for haemophilus to grow
heat labile nicotinamide mononucleotied (NAD) |
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What is the medium that haemophilus grows on?
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chocolate
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What defines whether we have a problem with haemophilus?
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the presence of a capusule
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Which is hemin + parainfluenza or infulenza?
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+ infulenza
- parainfulenza |
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Which is NAD + parainfulenza or infulenza?
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+ pareinfluenza
- influenzae |
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H. influenzae
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associated w human disease
upper respiratory, no encapsulated and not virulent man is only natrual host |
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What is the most important serotype of Haemophilus influenzae?
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serotype B casue it contains pentose rather than hexose
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What is the pathogensis of haemophilus influenzae?
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primary infection of nasopharynx with occasional invasion of sinuses, middle ear, bronchi & may get in the blood stream
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Who gets haemophilus menigitis?
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the very young
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There is an inverse relationship between what in h. meningitis?
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Ab and incidence of the disease
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What is Hib?
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vaccine from purified polysaccharide
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What is the problem using polysaccharides as vaccines?
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poor Ag
stimulates T-independent Ab immunity poor memory |
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What is the 2nd generation of the Hib vaccine?
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PRP conjugates
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What are the characateristics of bordetella?
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gram negative coccobacilli -> pleomorphic
strict aerobes |
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What are the 3 main species of bordetella?
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b. pertussis - whooping cough
b. parapertussis - mild b. bronchoseptica - respirator disease in animals |
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Which of the 3 specicies of bordetella produce the pertussis toxin?
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b. pertussis only
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Clinically B. pertussis?
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highly infectious
humans only known carriers assymp adult to a child |
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Let's talk about the pertussis vaccine
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whole cell is locally reactive due to LPS
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Where does pertussis infect?
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the ciliated cell of hte upper respiratory tract
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What is the name of the pertussis vaccine?
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DTP
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When do symptoms develop with b. pertussis?
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10 days after the exposure
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What are the 3 stages of pertussis infection?
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1. Catarrhal
2. Paroxysmal 3. Convalescence |
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What is the catarrhal stage of pertussis infection?
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stage 1
1-2 weeks mild sx with grownig bacteria |
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What is the parozysmal stage of pertussis infection?
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Stage 2
1-6wks hacking cough w. mucus or vomitting and a whoop |
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What is the convalescence stage of pertussis infection?
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stage 3
coughing persists for several months |
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What are the properties of pertussis toxin?
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A: ADP ribosylates
B: Gi decreases adenylate cyclase A:5B |
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What is the Tx of pertussis?
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erythromycin
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What is the new type of pertusiss vaccine?
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acellular
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What is the main similarity between bordetella and haemophilus?
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humans are only known reservoir
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