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57 Cards in this Set
- Front
- Back
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List the obilgate intracellular pathogens
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coxiella
rickettsia chlamydia chlamydophilia ehrlichia mycobacterium leprae |
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List the intracellular pathogens
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legionella
salmonella shigella enteroinvasive e. coli mycobacterium TB |
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List the epicellular pathogens
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bartonella
mycoplasma |
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What is the key feature of intracellular pathogens?
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cannot replicate outside the host
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What is the key feature of the facultative intracellular pathogen?
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can be cultivated in the absence of host cells
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What is the key feature of epicellular pathogens?
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closely associated with host cells but can be cultivated axenically in medium with additives
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What is the main exception for rickettsia... no rash and no insect vector?
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coxiella
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What are the characteristics of rickettsiae?
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gram negative bacilli - small
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How are rickettsiae transmitted?
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arthropods -> zoonoses
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What does the spotted fever rickettsiae group include?
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rocky mountian spotted fever
boutonneuse fever rickettsial pox |
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What does the typhus group of rickettsiae include?
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epidemic typhus
Murine Typhus scrub typhus |
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What causes rocky mountain spotted fever?
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r. rickettsii
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Who is most likely to get rocky mountain spotted fever?
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children
elderly aa men with G6P dehydrogenase deficiency |
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What is the mechanism of transtmission of R. ricketsii?
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female ticks to infected ova that hatch infected larval offspring
tick bite transmits |
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Q fever is caused by?
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coxiella
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What causes ehrlichiosis?
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ehrlichia
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What are the sx of rickettsialpox?
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R. akari
fever, blister like rash, necrosis mice |
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What are the sx of boutonneuse fever?
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r. conorii
travelers from mediteranean, kenya, south africa |
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What are teh sx of Epidemic typhys and brill-Zinsser Disease?
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R. prowazekii
war and disaster lice latent diseast the can re-emerge |
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What are the sx of Ehrlichiosis?
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ehrlichia chaffeensis
fever, leukopenia Lone star tick low golf scores |
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What is the life cycle of rickettsial?
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enter through skin, spread through bloodstream, infect endothelium, rickettsial attatchment, escape the phagosome, replicate
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Pathogenesis of r. prowazekii
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epidemic typhus
little cellular path massive # of org b4 host cell lysis possibly mediated by phsophlipase |
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Pathogensis of r. rickettsii
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rocky mountain fever
highly cytotoxic few accumulate intracellularly and the host via filopodia to spread |
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How does rickettsia survive in the cell?
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escape the phagosome
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Hoe does ehrlichia survive in the cell?
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inhibition of phagosome lysosome fusion
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How does coxiella survive in the cell?
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replicated in the phagolysosome
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What does rocky mountain spotted fever look like?
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abrupt onset of fever, chill headache myalgia 2-12 d after bite
rash 2-3d later on palms/soles maculopapular to petechial rash -> vasculitis |
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What does epidemic typhys look like?
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sudden onset of fever, chills, headache, myalgia and arthralgia
rash starts on trunk & spreads 8 days recovery may take several mo |
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What does Brill-Zinsser disease look like?
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occurs decades after initial infection
similar to typhus but milder rash is rarely seen |
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What can chlamydia not do?
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make their own ATP
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What are the 2 types of infections that chlamydia trachomatis causes?
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ocular infections (trachoma)
STD |
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What does the ocular infection of chlamydia look like?
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trachoma
severe infection of epitheilal cells fibroblasts invade causing cornea to be clouded inward growth of eyelashes blindness |
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what does the STD chlamydia look like?
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lymphogranuloma venereum
chronic cervicitis nongonococcal urethritis |
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What does chlamydophila psittaci cause?
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psittacosis
pneumonia |
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What does chlamyldophlia pneumoniae cause?
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pneumonia
bronchitis sinusitis |
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how is trachoma spread?
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flies, fingers, towels, cosmetics
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How is psittacoais spread?
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birds
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What is chlamydia associated with?
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atherosclerosis and chronic infections
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What is an elementary body?
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infectious non-dividing form of chlamydia
no metab activity rigid cell envelope |
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What is a reticular body?
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dividing non-infectious form of chlamydia
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What is the distinguishing charactersistic of chalmydia on a slide?
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inculsion bodies
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What does a chlamydia infection evoke?
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formation of BV, CT, lymphocyitic infiltration (pannus)
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What is the host response to chalmydia?
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chronic inflammation
Ab but they dont prevent reinfetions but bind EB the dont help |
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What is the tx of chlamydia?
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tetracycline
erythromycin sulfanomides |
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What are the characteristics of mycoplasma?
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smallest free living
no cell wall! |
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M. pneuomniae
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atypical pneumonia
development of Ab that agglutionate RBCs upper respiratory disease w gradual onset |
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What part of the lungs do you see m. pneumoniae in?
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the lower lobes
interstitial or bronchopneumonic |
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Ureaplasma urealyticum?
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nongonoccal urethritis in men free of chlamydia trachomatis
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What is ureaplasma associated with?
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chorioamnionitis
spontaneous abortion low-weight infants |
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Mycoplasma hominis
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common inhabitant of GU tract in wowmat contribute to PID and tuboovarian abscess adn salpingitis
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M genitalium
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male urethritis
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What 2 long term disease may be associated with mycoplasmas?
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AIDs
arthritis |
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What are the characteristics of mycoplasma?
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cocci with filamentous forms
fried egg appearance need cholesterol to grow!!! slow growing |
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What is a unique growth requirement of ureaplasma?
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urea... duh!
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What is the pathogenesis of mycoplamas?
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surface associated
local accum of toxic metab & oxidation of lipids Major Mycoplasma Adhesion P1!! may involve autoimmunity |
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What is the epidemiology of mycolplasma?
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children 5-9 - pneumonia
year round but more winter incubation period 2-3 weeks |
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What can you not use to tx mycoplama?
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cell wall inhibitors... they have no cell wall!
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