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28 Cards in this Set

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  • Back
What are 3 properties of a successful pathogen?
1. gain access into host
2. colonize host tissue
3. resist host defense mech
4. damage host
Injection salmonella into mice which way is more toxic, oral or subcuatneous?
subcutaneous
What is a major property of invasive bacteria?
capsule
What are properties of exotoxins?
in both grm +/-
heat labile
doesnt include fever
toxic in low doses
What are the 4 classes of bacterial toxins?
surface acting
pore-forming
A/B
Type III and IV secretion
What are some types of covalent modification to host macromolecules?
ADP-ribosylation
proteolysis
glucosylation
deamidation
deadenylation
What is a protoxin?
toxin that is stable and not active until it is modified
What is the A component?
catalytic
What is the B component?
binding
What is the mech of action of diptheria toxin?
ADP-ribosylation and activates elongation factor 2
What is the role of diptheria toxin in the disease?
inhibition of protein synth in animal cells
What is the mech of action of cholera toxin?
ADP-riboslyates G proteins to stimulate adenylate cyclase
What is the role of cholera toxin in the disease?
promotes secretion of fluid and electrolytes in GI
What is the mech of action of pertussis toxin?
ADP-ribosylates G protien to inhibit adenylate cyclase
what is the mech of action of E.coli heat labile toxin?
ADP- ribosylates G protein to stimulate adenylate cyclase
What is the role of heat labile ecoli toxin in the disease?
promotes secretion of fulid and electrolytes from GI
What is the mech of action of ecoli heat stable toxin?
activates guanylate cyclase
What is the role of heat stable echoli toxin in the disease?
promotes secretion of fulid and electrolytes from GI
Carrier for cojugate vaccines (hib) with diptheria
CRM 197 a pt mut within DT that inactivates the toxin
Non-lysogenic strains of diptheria
colonize upper respiratory tract and produce a local infection but no systemic
Lysogenic strain of diptheria toxin
colonize upper respiratory tract and produce local infection adn toxins for a systemic effect
What organs does diptheria effect systemically?
heart -> death
liver
lung
NS
Entry of diptheria toxin into eukaryotic cells is by?
receptor mediated endocytosis
What does DPT stand for?
D-Diptheria
P-pertussis
T-tetnis
Active cases of diptheria can be treated with?
antitoxin
How does antitoxin work?
neurtralizing Ab against the receptor domain of DT
What is DT/TT vaccine?
formlain inactivated diptheria and tetanus toxins
What is the hib vaccine?
made by conjugation to several different protiens including a nontoxic for of DT (CRM 197)