Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
28 Cards in this Set
- Front
- Back
|
What are 3 properties of a successful pathogen?
|
1. gain access into host
2. colonize host tissue 3. resist host defense mech 4. damage host |
|
|
Injection salmonella into mice which way is more toxic, oral or subcuatneous?
|
subcutaneous
|
|
|
What is a major property of invasive bacteria?
|
capsule
|
|
|
What are properties of exotoxins?
|
in both grm +/-
heat labile doesnt include fever toxic in low doses |
|
|
What are the 4 classes of bacterial toxins?
|
surface acting
pore-forming A/B Type III and IV secretion |
|
|
What are some types of covalent modification to host macromolecules?
|
ADP-ribosylation
proteolysis glucosylation deamidation deadenylation |
|
|
What is a protoxin?
|
toxin that is stable and not active until it is modified
|
|
|
What is the A component?
|
catalytic
|
|
|
What is the B component?
|
binding
|
|
|
What is the mech of action of diptheria toxin?
|
ADP-ribosylation and activates elongation factor 2
|
|
|
What is the role of diptheria toxin in the disease?
|
inhibition of protein synth in animal cells
|
|
|
What is the mech of action of cholera toxin?
|
ADP-riboslyates G proteins to stimulate adenylate cyclase
|
|
|
What is the role of cholera toxin in the disease?
|
promotes secretion of fluid and electrolytes in GI
|
|
|
What is the mech of action of pertussis toxin?
|
ADP-ribosylates G protien to inhibit adenylate cyclase
|
|
|
what is the mech of action of E.coli heat labile toxin?
|
ADP- ribosylates G protein to stimulate adenylate cyclase
|
|
|
What is the role of heat labile ecoli toxin in the disease?
|
promotes secretion of fulid and electrolytes from GI
|
|
|
What is the mech of action of ecoli heat stable toxin?
|
activates guanylate cyclase
|
|
|
What is the role of heat stable echoli toxin in the disease?
|
promotes secretion of fulid and electrolytes from GI
|
|
|
Carrier for cojugate vaccines (hib) with diptheria
|
CRM 197 a pt mut within DT that inactivates the toxin
|
|
|
Non-lysogenic strains of diptheria
|
colonize upper respiratory tract and produce a local infection but no systemic
|
|
|
Lysogenic strain of diptheria toxin
|
colonize upper respiratory tract and produce local infection adn toxins for a systemic effect
|
|
|
What organs does diptheria effect systemically?
|
heart -> death
liver lung NS |
|
|
Entry of diptheria toxin into eukaryotic cells is by?
|
receptor mediated endocytosis
|
|
|
What does DPT stand for?
|
D-Diptheria
P-pertussis T-tetnis |
|
|
Active cases of diptheria can be treated with?
|
antitoxin
|
|
|
How does antitoxin work?
|
neurtralizing Ab against the receptor domain of DT
|
|
|
What is DT/TT vaccine?
|
formlain inactivated diptheria and tetanus toxins
|
|
|
What is the hib vaccine?
|
made by conjugation to several different protiens including a nontoxic for of DT (CRM 197)
|
