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20 Cards in this Set
- Front
- Back
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diagnostic for S. Aureus
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B hemolysis
yellowish to golden colony high salt 7.5% catalase when aerobically grown |
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how to differentiate S. epidermidis/saprophyticus from S. aureus
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NO hemolysis
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where are staph found?
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S. Ep/sap- Skin- normal flora
S. aureus- nose |
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6 virulence factors of staph
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Capsular polysaccharide
Teichoic acid peptidoglycan protein A (aureus only) clumping factor- coagulase altered Penecilling binding protein cell surface binding sites for mamalian proteins |
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7
extracellular prducts of staph (to establish infection) |
coagulase
catalase hyaluronidase staphylokinase lipase nuclease penicilinase- B lactamase |
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Toxins of Staph
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a toxin- permeabilize target membrane
B toxin- sphingomyelinase C D toxin- detergent G toxin Leukocidin-> PMN membranes exfoliative-> desmoglein enterotoxin- heat stabile, superantigen like TSST-1 |
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6
S. aureus clinical syndromes |
skin- impetigo, furuncle, carbuncle, folliculitis
SSSS TSS food poisoning wound infections bacteremia- endocarditis, pneumonia, osteomyelitis, septic arthritis |
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2 syndromes of S. epidermitidis
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endocarditis
prosthetics/shunt infection |
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S. saprophyticus
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UTI
resistant to novobiocin |
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clinical Dx of S. saprophyticus
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Novobiocin resistance
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Strep A virulence factors
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capsule: HA
peptidoglycan cell wall M protein LTA |
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Strep A extracellular products
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streptolysin O
streptokinase streptodornase Hyaluronidase pyrogenic exotoxins A-C C5a peptidase protease |
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diseases of Strep A
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pharyngitis
impetigo peurperal sepsis erysipelas lymphangitis, lymphadeniits sepsis STSS |
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Lab ID of strep A
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ASO ADB- post infectious
ELISA- rapid test |
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Group B strep diseases
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neonatal sepsis, meningitis
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Gropu B strep lab ID
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CAMP test
blood csf, genital cultures |
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Gropu D lab ID
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G hemolytic
bile esculin 6.5% NaCl- enterococci |
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normal flora of S. viridians
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upper repiratory tract
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Viridians syndromes
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cavities
SBE |
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S. pneumoniae lab ID
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quelling
optochin sensitivity mouse virulece |
