Bacterial Toxins

Front 1

Name the bacteria (3) and their toxins (4):

Exotoxin causes increase in [cAMP] or [cGMP]

Back 1

B. pertussis→pertussis toxin
(increase cAMP→inhibit bactericidal activity)

E.coli→ST & LT toxin
(ST toxin: increase cGMP; LT toxin increase cAMP; both→watery diarrhea)

V. cholerae→cholera toxin
(increase cAMP→intestine secrete more Cl- and absorb less Na=osmotic loss of fluid in diarrhea)

Front 2

B. pertussis

Back 2

pertussis toxin

(AB: B causes inactivation of Gi so increase cAMP→inhibit bactericidal activity)

Front 3

E.coli (2)

Back 3

B. pertussis→pertussis toxin
(increase cAMP→inhibit bactericidal activity)
ST & LT toxins

(ST toxin: increase cGMP; LT toxin increase cAMP; both→watery diarrhea)

Front 4

V. cholerae

Back 4

cholera toxin

(AB5: B activates Gs so increase cAMP→intestine secrete more Cl- and absorb less Na=osmotic loss of fluid in diarrhea)

Front 5

Bacteria and their toxins (4) that secrete exotoxin to...

inhibit protein synthesis

Back 5

C. diptheriae→diptheria toxin
P. auriginosa→exotoxin A
S. dysenteriae→shiga toxin (bind 60s ribosome)
E. coli→shiga-like toxin

Front 6

S. dysenteriae

Back 6

shiga toxin (bind 60s ribosome→inhibit protein synthesis)

Front 7

C. diptheriae

Back 7

diptheria toxin (inhibit protein synthesis)

Front 8

P. auriginosa

Back 8

exotoxin A (inhibit protein synthesis)

Front 9

B. anthracis

Back 9

anthrax toxin
3 proteins (PA, EF, LF) cause dermal necrosis

Front 10

S. aureus

Back 10

TSST-1 (superantigen that promotes excess cytokine release→toxic shock)

Exfoliative toxin (scalded skin syndrome)

Enterotoxin/heat stable toxin (food poisoning from premade toxin