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8 Cards in this Set
- Front
- Back
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Mycoplasma pneumoniae
morphology & culture requirements |
--smallest, free-living reproductive units
--pleomorphic, stain poorly, "fried egg", NO CELL WALL --triple membrane w/sterols --complex media(lipoprotiens, sterols, 5% CO2) |
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Mycoplasma pneumoniae
transmission epidemiology |
epi: #1 cause of PAP in ages 5-15 (25-50% all PAP, 10-15% all), human-only
transmission: P --> P via resp. secretions |
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Mycoplasma pneumoniae
Pathogenisis/Virulence factors Clinical manifestations |
pathogenisis: interferes with ciliary action by adhesion via P1 adhesin
Sx: Insidious onset (1-3 wk inc), non productive cough, fever, headache, sore throat, malaise, self limiting, CXR--patchy infiltrate |
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Mycoplasma pneumoniae
Dx Tx |
Dx: primarily clinical b/c culture takes too long, antigen-specific serology (most people have ab), 1:64 cold agglutination titer
Tx: doxycycline, erythromycin, tetracycline, but usually self limiting RESISTANT TO CELL WALL INHIBITORS! |
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Legionella pneumophila
--morphology --culture requirements |
morph: aerobic G(-) rod, silver stain
--catalase +, oxidase + --facultative intracellular culture: buffered charcoal yeast extract agar |
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Legionella pneumophila
• Transmission • Epidemiology Control |
TRANS: inhalation from A/c, showers, etc. (NOT P2P)
EPI: Older men w risk factors most suscept. --live in ameoba --assoc. with noscomial outbreaks Control: hyperchloranation, elevated water temp, cu-ag ionization |
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Legionella pneumophila
• Pathogenesis/Virulence Factors • Clinical Manifestations |
path: facultative intracellular--inhibits phagosome-lysosome fusion
--affects alveoli and bronchioles Sx: GI SX in ~50% *** --high fever (103-4) --could affect other organs |
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Legionella pneumophila
Dx Tx |
Dx: Difficult to gram stain
--culture on BCYE --antigen specific LPS in urine test good for community acquired serotype Tx: macrolides, azithromycin, fluoroquinolones-levofloxin |
