Bacterial Pathogenesis 1

Front 1

vancomycin

Back 1

gram (+) cell wall, by IV

Front 2

penicillin

Back 2

cell wall, beta lactam ring

Front 3

kanamycin

Back 3

prot synth, binds bacterial ribosome

Front 4

tetracycline

Back 4

prot synth, binds bacterial ribosome

Front 5

azitromycin (Z-pack)

Back 5

prot synth, binds bacterial ribosome

Front 6

ciprofloxacin

Back 6

inhibits DNA rep, esp anthrax
kills intracellular path

Front 7

rifampin

Back 7

inhibits RNA polymerase
kills intracellular path

Front 8

trimethoprim/sulfamethoxazole

Back 8

inhibits 2 steps of folate synth

Front 9

augmentin

Back 9

clavulonic acid + penicillin

inhibits beta lactamase

Front 10

myeloid cells

Back 10

GEMM.
granulocytes (PMN)
erythrocytes (rbcs)
monocytes (macrophage)
megakaryocytes (platelets)

Front 11

lymphoid cells

Back 11

B, T, NK

Front 12

granulocytes

Back 12

neutrophils (phagocytes)
eosinophils (extracel para worms)
basophils (histamine, inflam)

Front 13

agranulocytes

Back 13

monocytes
lymphocytes (B/T/NK)

Front 14

C3a

Back 14

vasodilation of blood vessels
stim mast cell release of histamine

Front 15

C3b

Back 15

opsonin, facilitate phago uptake

Front 16

C5a

Back 16

vasodilation, also opsonin

Front 17

MAC

Back 17

C5b,C6-C9. kills gram (-) path

Front 18

control complement activation

Back 18

C3bfH. degraded by serum protein I

Front 19

MODS

Back 19

multiple organ disfunction syndrome

Front 20

ARDS

Back 20

acute respiratory distress syndrome

Front 21

pulmonary edema

Back 21

wet lung

Front 22

IgG

Back 22

best opsonin
neutralizes toxin
crosses placenta
ADCC

Front 23

ADCC

Back 23

Ab-dependent cell-mediated cytotoxicity. IgG mediates NK/PMN attachment to infected cell/tissue

Front 24

IgM

Back 24

best complement activator, one molecule needed.

Front 25

sIgA

Back 25

best at trapping bacteria (mucin)
toxin neutralization

Front 26

IgE

Back 26

prevents worm infections
causes allergic response
binds to mast cells w Ag, release histamine

Front 27

perforin

Back 27

makes holes in host cell membrane

Front 28

granzymes

Back 28

enzymes to induce apoptosis

Front 29

types of toxins.

Back 29

endo,
protein exo (AB, membrane disrupting, superAg)

Front 30

clostridium

Back 30

gram (+) rods
motile
anaerobic
spores
from soil

Front 31

staphylococcus

Back 31

gram (+) cocci
nonmotile
aerobic

Front 32

streptococcus

Back 32

gram (+) cocci
nonmotile
aerobic

Front 33

corynebacterium

Back 33

gram (+) clubs
nonmotile
facultative anaerobe

Front 34

yersinia

Back 34

gram (-)
nonmotile (or entero motile/25, not 37)
facultative anaerobe

Front 35

SIRS

Back 35

systemic inflammatory response syndrome

Front 36

sepsis

Back 36

blood poisoning

Front 37

hypotension

Back 37

low blood pressure

Front 38

refractory hypotension

Back 38

low bp despite fluid administration

Front 39

monocyte

Back 39

becomes macro later
circulates in blood
lives 4-5wks

Front 40

macrophage

Back 40

APC
circulates
fixed in tissue
lives weeks

Front 41

polymorphonuclear leukocytes

Back 41

PMNs/wbcs/neutrophils
most abundant (circulate)
first phago at infections

Front 42

Tc cells

Back 42

CD8+
deliver toxic granules to host cells specifically infected (intracellular path)

Front 43

NK cells

Back 43

deliver toxic granules to host cells infected with a variety of intracellular path

Front 44

MBL

Back 44

mannose-binding lectin

Front 45

gram (+)

Back 45

LTA on cytosolic membrane
TA on cell wall

Front 46

gram (-)

Back 46

inner membrane
cell wall
outer membrane with LPS

Front 47

PAMPs

Back 47

pathogen associated molecular patterns

Front 48

tachycardia

Back 48

high heart rate

Front 49

DIC

Back 49

disseminated intravascular coagulation

Front 50

BoNT

Back 50

protease, superpotent, prevents syn vesicle release of ACh.
attacks PNS, causes flaccid muscle paralysis

Front 51

TeNT

Back 51

B binds to CNS, prevents GABA inhibitor, muscles cant relax, spastic paralysis/respiratory failure.

Front 52

alpha toxin

Back 52

phospholipase, fr perfringens, dissolves host membs, causes gas gangrene/myonecrosis

Front 53

CPEA

Back 53

C perfringens endotox A. disrupts epithelial cell memb

Front 54

TSST-1

Back 54

cause TSS, superAg, non-spec stim and cytokine storm (1/5 Tc stim)

Front 55

SPE

Back 55

Streptococcal Pyogenic Exotoxin, pus producing. causes TSLS

Front 56

bacteriocidal

Back 56

kills pathogens

Front 57

bacteriostatic

Back 57

inhibits pathogens

Front 58

therapeutic index

Back 58

efficacy/toxicity

Front 59

DT

Back 59

after throat colonization, goes to blood, heart/PNS, helps w respiratory difficulties/heart failure

Front 60

HB-EGF. B from DT binds to this

Back 60

heparin binding epidermal growth factor precursor

Front 61

ADP ribosylation

Back 61

mech of DT toxin. from NAD to EF-2

Front 62

Hib

Back 62

Haemophilus influenzae type B. vacc from DT (B) toxoid

Front 63

YST

Back 63

Yersinia heatstable enterotoxin. inflam response in abs

Front 64

YSC

Back 64

type III secretion. molecular syringe, injects toxin

Front 65

Yops

Back 65

plasmid encoated Y outer memb prots
inhibit phago
raise macrophage apoptosis

Front 66

F1 capsule

Back 66

anti phago prot capsule, from pMT1

Front 67

Ymt

Back 67

Y. murine toxin, promotes flea colonization

Front 68

Pla protease

Back 68

plasminogen activator protease.
disrupts blood clotting (free path)
degrades C3b/C5a
best at 37˚

Front 69

pPCP1

Back 69

Pla protease

Front 70

pMT1

Back 70

Ymt and F1 capsule

Front 71

pCD1

Back 71

YSC
Yops
V antigen

Front 72

V antigen

Back 72

immunosuppressive to host