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13 Cards in this Set
- Front
- Back
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Tetanospasmin
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Heavy - binds to neuronal gang
Light - inhibits neurotransmitters (GABA, glycine) |
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Botulinum
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Inhibits Ach
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Choleragen
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Five B subunits: bind to GM1 gang in intestinal cell memb
Two A subunits: ADP-ribosylate GTP-binding prot, increases cAMP, secreting NaCl and inhibits resorption |
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E coli heat labile toxin
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same thing as choleragen
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E coli heat stable toxin
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activates guanylate cyclase, increases cGMP, inhibits resroption of NaCl
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Shiga toxin
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Five B subunits: bind to intestinal epithelium
A subunit: inhibits 60S ribosomal subunit, kills intestinal cells (get bloody diarrhea) |
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Group A Strep pyogenes - M protein
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antiphagocytic; adhesion mediated internalization by host, degrades C3b
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Streptococcus pyrogenic toxin
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aka erythrogenic toxin; acts as superantigen; releases IL-1, TNF-a, IFN-g, can lead to Scarlet fever and even TSS
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Toxic Shock Syndrome toxin (TSST-1)
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Usually from staph aureas; acts like super antigen, causing release of IL-1, TNF-a, IFN-g
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Streptococcus Streptolysin O
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oxygen labile; lyses leukocytes, platelets, RBCs
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Strep agalactiae
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lives in vagina, colon
causes: neonatal meningitis, pneumonia, sepsis |
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Strep viridans
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lives in oropharynx, GI, GU
causes: dental plaque, subacute endocarditis, intra-abdominal infections, abscesses |
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Group D strep - Enterococcus (faecialis, faecium)
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grows in 40% bile, 6.5 NaCl
Diseases: Urinary, Biliary, Cardiovascular Infections, Subacute endocarditits (SBE) |
