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15 Cards in this Set
- Front
- Back
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What are the gram negative bacilli ?
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E Coli
Enterobacter Shigella and Salmonella H. influenzae Psuedemonas Klebsiella Campylobacter |
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What class of bacilli is Neisseria and what does it cause ?
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Gram NEGATIVE, causes gonorrhea and meningitis
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What does mycobacteria cause ?
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TB, leprosy
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What does chlamydia cause ?
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cervicitis and pnuemonia
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What does mucoplasma cause ?
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pnuemonia
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What does Legionalla cause ?
What about Rickettsia ? |
Legionnaires Disease
Rickettsia causes Rocky Mountain spotted fever and Typhus |
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What do spirochetes cause ?
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Lymes disease, syphilis and yaws
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What are the goals of antimicrobial therapy ?
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Safe
Effective Cost effective |
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Describe the rational approach to antimicrobial therapy...
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Integrate kinetic activity
Develop a target concentration Base dosing on kinetic and patient factors Evaluate efficacy based on clinical vs. bacteriological response Monitor safety |
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List the Cockgroft Gault Equation
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140 - age X IBW
____________________ 72 x Serum Cr. X 0.85 (females) |
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What are the rules of the CG equation ?
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If they are older than 90, use 90
* If sc < 1.0, use 1.0 * if weight is less than IBW, use real weight *if obese, use IBW |
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What are the dosing guidelines in antibiotics for hepatic insufficiency ?
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Reduce the dose by 50% for those with severe liver failure
**use drugs that are cleared renally***** |
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What are the FOUR mechanisms of actions of antibiotics ?
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1.)Inhibit bacterial wall synthesis
2.)Inhibit protein synthesis (by binding either 50 or 30's ribosomes) 3.)Affects RNA 4. Inhibits folic acid |
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What is the MIC?
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the lowest concentration of antiobitic in the serum needed to inhibit the growth
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When comparing antibiotics, what does a low MIC imply ?
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The lowest MIC may be indicative of the most potent drug
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