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21 Cards in this Set
- Front
- Back
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Bortezomib is what?
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proteasome inhibitor used in multiple myeloma
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What are the three phases of clinical testing of new drugs
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Phase I: define a safe dose; Phase II: Efficacy toward specific tumors; Phase III: Compare with current treatment
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What is Group C status?
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allows use of drug before FDA approval
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How is immune surveillance of tumors mediated?
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T cell mediated
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What does IL-2 do?
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Used in Renal Cell carcinoma; adoptive immunotherapy (in vitro activation of patients lymphocytes (LAK) cells or clonal expansion of tumor infiltrative lymphocytes
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What is the source of INF-alpha?
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Leukocytes
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What is the source of INF-beta?
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FibroBlasts
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What is the source of INF-gamma?
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T-cells
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What is Interferon induced by?
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double stranded RNA
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What is interferon used for
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Hairy cell leukemia; chronic phase of CML; Hepatitis B and C; Lesser - Kaposi's sarcoma, some efficacy in renal carcinoma, melanoma, and multiple myeloma
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What two agents are used to enhance bone marrow recovery?
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Granulocyte Colony Stimulating Factor (GCSF); Granulocyte/macrophage colony stimulating factor (GMCSF)
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What is the MOA for GCSF?
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produced by macrophages, fibroblasts, endothelial cells; expands granulocyte precursores and enhances granulocyte function
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What is the MOA for GMCSF?
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produced by activated T cells, macrophages, fibroblasts, endothelial cells; acts earler in the differentiaion pathway of stem cells
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What is the use of GCSF?
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prevent neutropenia associated with chemotherapy
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What is the use of GMCSF?
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same as GCSF, also in bone marrow transplants
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What are retinoids used in?
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promyelocytic leukemia; high dose retinoic acid induces differentiation of leukemic cells
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What is herceptin used for?
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ab that targets tumor cells; binds to HER2 and blocks its action
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What is the MOA of Imatinib mesylate?
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inhibitor of tyrosine kinase; arrests bcr-apl which is a hyperactive tyrosine kinase
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What is imatinib mesylate used in?
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CML!
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What are two natural inhibitors of vascularization?
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Angiostatin and endostatin
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Bevacizumab. MOA.
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antibody that inhibits VEGF
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