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15 Cards in this Set
- Front
- Back
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What cytokine secreted by CD4+ Th1 cells stimulates macrophages to come?
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IFN-gamma
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What does TNF and IL-1 do after they are released by activated macrophages?
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Pro-inflamation (endothelial activation and acute phase reactions)
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What does C3a do after it is released from a plasma protein?
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opsonization
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What does C5a do after it is released from macrophages?
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stimulate leukocyte activation and adhesion (recruitment)
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Does TNF and IL-1 cause vascular leakage?
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No!
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So what type of CD4+ cells exist?
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Th1 and Th2
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What does a CD4+ Th1 release?
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IL-2 and IFN-gamma
*kill by activating macrophages and make opsinization agents |
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What deos a CD4+ Th2 release?
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IL-4, IL-5, IL-13
*activate production of IgE, stimulate Eosinophils |
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How do you develop Hyper IgM Syndrome?
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A deletion of the CD40-ligand on activated T cells..unable to stimulate CD40 on B cells so no production of IgG, IgA, IgE
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The cylcooxygenase pathway does what?
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mediates angiogenesis, wound healing and mucus production
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What chemokine attracts Neutrophils to the site of infection?
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TGF-beta
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What antibody is produced in response to non-protein antigen i.e polysaccharides and lipids?
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IgM
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IgG,IgA,IgE produciton require co-stimulation of what receptors on B and T cells?
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CD40 and CD40-Ligand
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What cytokine causes T cells to proliferate after the appropiate co stimulaiton is povided by the APC?
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IL-2
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What are some co-stimulatory signals required to activate MHC I or II?
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B7
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