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15 Cards in this Set

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What cytokine secreted by CD4+ Th1 cells stimulates macrophages to come?
IFN-gamma
What does TNF and IL-1 do after they are released by activated macrophages?
Pro-inflamation (endothelial activation and acute phase reactions)
What does C3a do after it is released from a plasma protein?
opsonization
What does C5a do after it is released from macrophages?
stimulate leukocyte activation and adhesion (recruitment)
Does TNF and IL-1 cause vascular leakage?
No!
So what type of CD4+ cells exist?
Th1 and Th2
What does a CD4+ Th1 release?
IL-2 and IFN-gamma
*kill by activating macrophages and make opsinization agents
What deos a CD4+ Th2 release?
IL-4, IL-5, IL-13
*activate production of IgE, stimulate Eosinophils
How do you develop Hyper IgM Syndrome?
A deletion of the CD40-ligand on activated T cells..unable to stimulate CD40 on B cells so no production of IgG, IgA, IgE
The cylcooxygenase pathway does what?
mediates angiogenesis, wound healing and mucus production
What chemokine attracts Neutrophils to the site of infection?
TGF-beta
What antibody is produced in response to non-protein antigen i.e polysaccharides and lipids?
IgM
IgG,IgA,IgE produciton require co-stimulation of what receptors on B and T cells?
CD40 and CD40-Ligand
What cytokine causes T cells to proliferate after the appropiate co stimulaiton is povided by the APC?
IL-2
What are some co-stimulatory signals required to activate MHC I or II?
B7