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26 Cards in this Set
- Front
- Back
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What chemical mediators of inflamation cause FEVER?
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IL-2, TNF, Prostaglandins
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What chemical mediators of inflamation cause PAIN?
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Prostaglandins, Bradykinin
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What chemical mediators of inflamation cause Vasodilation?
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Prostaglandins(PG-F,D, PGI-2), Histamine, Lipoxins
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What chemical mediators of inflamation cause Vasoconstriction?
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Leukotriens (LT-C,D,E), TXA
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What chemical mediators of inflamation cause INCREASED VASCULAR PERMEABILITY?
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Leukotrines (LT-C,D,E), Bradykinin, C5a, C3a, PAF, Substance P,
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What chemical mediators of inflamation cause Chemotaxis?
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Bacterial products, LT-B, C5a, IL-1, TNF
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What chemical mediators of inflamation cause Coagulation by increasing Fimbrin?
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TXA, Thrombin (via Hagamen Factor produced in the liver after tissue damage)
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What chemical mediators of inflamation cause Anti-Coagulation?
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Prostaglandins (PG-F,D), PGI-2
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What does Lipoxin inhibit?
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Chemotaxis and LT-C,D,E action
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What else does the Hagamen factor produce?
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Kilikrein that converts C5 and C3--> C5a and C3a ---> cause inflamation
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What does the Fibrinolytic Pathway within the KININ Pathway cause?
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Prevents clots from forming by destroying FIMBRIN
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What does the Intrinsic Pathway cause?
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Promotes clotting by activating FIMBRIN
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What intermediates are found in the Fibrinolytic Pathway?
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Killikrein, Plasmin, fimbrin
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What intermediated are found in the Intrinsic Pathway?
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Factor X, Thrombin, Fibrinogen, fimbrin
*thrombin also activates Acute Inflamation |
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What does Factor VIIa derived from the Liver's Hageman Factor activate?
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Activates Intrinsic (clot) and Kinin(no clot) pathway
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What does C1 do in the compliment pathway?
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C1 converts (C4-->C4a+b and C2-->C2a+b) which form a C3 Convertase
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How is C1 activated?
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1. Ab (IgG and IgM)
2. MBL |
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How does the MAC complex form?
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Begins with the fusion of C3b + C5b and eventually leads to formation of poor with C9 --> lysis
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What components of the compliment system cause inflamation by increasing vascular permeability and stimulate chemotaxis?
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C3a and C5a
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What component of the compliment system cause phagocytosis by macrophages and neutrophils via opsonization?
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C3b
*high amounts in Lupus |
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What are the functions of compliment activtion?
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1. Kill
2. recruit 3. opsonization |
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In the Alternative Pathway, what causes Factor B to break and eventually form the C3 convertase by binding C3a and Bb?
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Factor D
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What regulates C3 and C5?
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DAF
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What regulates C3b in the alternative pathway?
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Factor I
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What regulates C1?
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CiiNH
*when not present causes edema |
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What controls the MAC complex?
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CD59
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