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17 Cards in this Set

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  • Back
What is relationship between single channel current and actual membrane current?
A single channel conductance x the open probability is equal to the Actual membrane current. If you multiply the actual current x the # of channels equal the macroscopic current.
How many gates in the K+-delayed rectifier channel?
1 gate
What is the Probability of the K+ delayed rectifier channel being opened?
P= n^4
How many gates in the Na+ channel?
2 gates
What is the Probability of the Na+ channel being opened?
P= m^3xh
What states does the K+ delayed rectifier channel undergo before it becomes inactivted?
it goes from C1--> C2 --> Open--> Inactive
C2=resting state
What is special about the A-type K channels?
they have a ball and chain mechanism that inactivates channel
When is there no conductance of Na+ after sequential stimulation?
During the Absolute Refractory period i.e since their is no Na+ conductance then their is no AP
When is there partial conductance of Na+ after sequential stimulus?
During the Relative Refractory Period: Last about 10 ms
i.e Na+ conductance slowly increases
What controls the Space response (i.e Slow Depolarization) prior to reaching AP treshold?
Transient outward K+ channels
What causes pacemaker activity?
Ca++ dependant K-channels produce a slow after hyperpolirization causing a long resting period in where intracellular calcium prevent Vm from reaching AP threshold eventually Ca++ is lowered by Ca++-pumps which slowly repolarize
What Shapes Action Potentials?
Ca++dependant K-channels
What causes a FAST After-hyperpolarization?
voltage gated delayed rectifier K channels
What causes a SLOW Afterhyperpolarization?
Ca dependant K channels
Where does Ca++ come in through?
voltage gated Ca channels
What is the equation for single channel current i.e ohms law single channels currents?
i(open)= signal channel conductance x(Vm-Nerst potential)
What is the macroscopic membrane current equation?
i(open) x Open Probability x number of open channels