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### 17 Cards in this Set

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 What is relationship between single channel current and actual membrane current? A single channel conductance x the open probability is equal to the Actual membrane current. If you multiply the actual current x the # of channels equal the macroscopic current. How many gates in the K+-delayed rectifier channel? 1 gate What is the Probability of the K+ delayed rectifier channel being opened? P= n^4 How many gates in the Na+ channel? 2 gates What is the Probability of the Na+ channel being opened? P= m^3xh What states does the K+ delayed rectifier channel undergo before it becomes inactivted? it goes from C1--> C2 --> Open--> Inactive C2=resting state C1= What is special about the A-type K channels? they have a ball and chain mechanism that inactivates channel When is there no conductance of Na+ after sequential stimulation? During the Absolute Refractory period i.e since their is no Na+ conductance then their is no AP When is there partial conductance of Na+ after sequential stimulus? During the Relative Refractory Period: Last about 10 ms i.e Na+ conductance slowly increases What controls the Space response (i.e Slow Depolarization) prior to reaching AP treshold? Transient outward K+ channels What causes pacemaker activity? Ca++ dependant K-channels produce a slow after hyperpolirization causing a long resting period in where intracellular calcium prevent Vm from reaching AP threshold eventually Ca++ is lowered by Ca++-pumps which slowly repolarize What Shapes Action Potentials? Ca++dependant K-channels What causes a FAST After-hyperpolarization? voltage gated delayed rectifier K channels What causes a SLOW Afterhyperpolarization? Ca dependant K channels Where does Ca++ come in through? voltage gated Ca channels What is the equation for single channel current i.e ohms law single channels currents? i(open)= signal channel conductance x(Vm-Nerst potential) What is the macroscopic membrane current equation? i(open) x Open Probability x number of open channels